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Natural Products for Pancreatic Cancer Treatment: From Traditional Medicine to Modern Drug Discovery

1
College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea
2
Department of Pathology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea
3
Korean Medicine-Based Drug Repositioning Cancer Research Center, College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Md Soriful Islam
Nutrients 2021, 13(11), 3801; https://doi.org/10.3390/nu13113801
Received: 22 September 2021 / Revised: 20 October 2021 / Accepted: 21 October 2021 / Published: 26 October 2021
(This article belongs to the Special Issue Natural Products and Disease Prevention, Relief and Treatment)
Pancreatic cancer, the seventh most lethal cancer around the world, is considered complicated cancer due to poor prognosis and difficulty in treatment. Despite all the conventional treatments, including surgical therapy and chemotherapy, the mortality rate is still high. Therefore, the possibility of using natural products for pancreatic cancer is increasing. In this study, 68 natural products that have anti-pancreatic cancer effects reported within five years were reviewed. The mechanisms of anti-cancer effects were divided into four types: apoptosis, anti-metastasis, anti-angiogenesis, and anti-resistance. Most of the studies were conducted for natural products that induce apoptosis in pancreatic cancer. Among them, plant extracts such as Eucalyptus microcorys account for the major portion. Some natural products, including Moringa, Coix seed, etc., showed multi-functional properties. Natural products could be beneficial candidates for treating pancreatic cancer. View Full-Text
Keywords: pancreatic cancer; natural product; traditional medicine; apoptosis; angiogenesis; metastasis; drug resistance pancreatic cancer; natural product; traditional medicine; apoptosis; angiogenesis; metastasis; drug resistance
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MDPI and ACS Style

Kim, A.; Ha, J.; Kim, J.; Cho, Y.; Ahn, J.; Cheon, C.; Kim, S.-H.; Ko, S.-G.; Kim, B. Natural Products for Pancreatic Cancer Treatment: From Traditional Medicine to Modern Drug Discovery. Nutrients 2021, 13, 3801. https://doi.org/10.3390/nu13113801

AMA Style

Kim A, Ha J, Kim J, Cho Y, Ahn J, Cheon C, Kim S-H, Ko S-G, Kim B. Natural Products for Pancreatic Cancer Treatment: From Traditional Medicine to Modern Drug Discovery. Nutrients. 2021; 13(11):3801. https://doi.org/10.3390/nu13113801

Chicago/Turabian Style

Kim, Ahyeon, Jiwon Ha, Jeongeun Kim, Yongmin Cho, Jimyung Ahn, Chunhoo Cheon, Sung-Hoon Kim, Seong-Gyu Ko, and Bonglee Kim. 2021. "Natural Products for Pancreatic Cancer Treatment: From Traditional Medicine to Modern Drug Discovery" Nutrients 13, no. 11: 3801. https://doi.org/10.3390/nu13113801

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