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Article

Association between Milk Intake and Incident Stroke among Japanese Community Dwellers: The Iwate-KENCO Study

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Department of Hygiene and Preventive Medicine, Iwate Medical University, Yahaba 028-3694, Japan
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Department of Nursing Informatics, Graduate School of Nursing Science, St. Luke’s International University, Tokyo 104-0044, Japan
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Department of Health Science, Kyoto Prefectural University, Kyoto 606-8522, Japan
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Faculty of Humanities and Social Sciences, Iwate University, Morioka 020-8550, Japan
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Department of Health Food Sciences, University of Human Arts and Sciences, Saitama 399-8539, Japan
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Iwate Prefectural Advanced Critical Care and Emergency Center, Iwate Medical University, Yahaba 028-3694, Japan
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Health Care Center, Iwate University, Morioka 020-8550, Japan
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Department of Internal Medicine, Morioka Tsunagi Onsen Hospital, Morioka 020-0055, Japan
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Department of Neurosurgery, Iwate Medical University, Yahaba 028-3695, Japan
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Division of Nephrology and Hypertension, Department of Internal Medicine, Iwate Medical University, Yahaba 028-3695, Japan
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Stroke Center, Division of Neurology and Gerontology, Department of Internal Medicine, Iwate Medical University, Yahaba 028-3695, Japan
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Division of Hematology and Oncology, Department of Internal Medicine, Iwate Medical University, Yahaba 028-3695, Japan
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Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Iwate Medical University, Yahaba 028-3695, Japan
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Department of Information Science, Iwate Medical University, Yahaba 028-3694, Japan
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Iwate Health Service Association, Morioka 020-8585, Japan
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Center for Liberal Arts and Sciences, Department of Human Sciences, Iwate Medical University, Yahaba 028-3694, Japan
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The Research Institute of Strategy for Prevention, Tokyo 103-0006, Japan
*
Author to whom correspondence should be addressed.
Academic Editors: Lesley MacDonald-Wicks and Susanna C. Larsson
Nutrients 2021, 13(11), 3781; https://doi.org/10.3390/nu13113781
Received: 24 August 2021 / Revised: 12 October 2021 / Accepted: 20 October 2021 / Published: 25 October 2021
(This article belongs to the Special Issue Nutrition and Stroke Prevention: Can a Diet Save Your Brain?)
We aimed to evaluate the association between the milk consumption and incident stroke in a Japanese population, where milk consumption is lower than that of Western countries. In total, 14,121 participants (4253 men and 9868 women) aged 40–69 years, free from cardiovascular diseases (CVD) were prospectively followed for 10.7 years. Participants were categorized into four groups according to the milk intake frequency obtained from a brief-type self-administered diet questionnaire. The adjusted HRs of total stroke, ischemic stroke and haemorrhagic stroke associated with milk intake frequency were calculated using the Cox proportional hazards model. During the follow-up, 478 stroke cases were detected (208 men and 270 women). Compared to women with a milk intake of <2 cups/week, those with an intake of 7 to <12 cups/week had a significantly low risk of ischemic stroke in a model adjusting CVD risk factors; the HR (95% CI) was 0.53 (0.32–0.88). No significant associations were found in men. This study suggested that milk intake of 7 to <12 cups/week decreased the risk of ischemic stroke in Japanese women. Milk intake of about 1 to <2 cups/day may be effective in the primary prevention of ischemic stroke in a population with low milk intake. View Full-Text
Keywords: milk intake; stroke; prospective cohort study; Japanese population milk intake; stroke; prospective cohort study; Japanese population
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MDPI and ACS Style

Tanno, K.; Yonekura, Y.; Okuda, N.; Kuribayashi, T.; Yabe, E.; Tsubota-Utsugi, M.; Omama, S.; Onoda, T.; Ohsawa, M.; Ogasawara, K.; Tanaka, F.; Asahi, K.; Itabashi, R.; Ito, S.; Ishigaki, Y.; Takahashi, F.; Koshiyama, M.; Sasaki, R.; Fujimaki, D.; Takanashi, N.; Takusari, E.; Sakata, K.; Okayama, A. Association between Milk Intake and Incident Stroke among Japanese Community Dwellers: The Iwate-KENCO Study. Nutrients 2021, 13, 3781. https://doi.org/10.3390/nu13113781

AMA Style

Tanno K, Yonekura Y, Okuda N, Kuribayashi T, Yabe E, Tsubota-Utsugi M, Omama S, Onoda T, Ohsawa M, Ogasawara K, Tanaka F, Asahi K, Itabashi R, Ito S, Ishigaki Y, Takahashi F, Koshiyama M, Sasaki R, Fujimaki D, Takanashi N, Takusari E, Sakata K, Okayama A. Association between Milk Intake and Incident Stroke among Japanese Community Dwellers: The Iwate-KENCO Study. Nutrients. 2021; 13(11):3781. https://doi.org/10.3390/nu13113781

Chicago/Turabian Style

Tanno, Kozo, Yuki Yonekura, Nagako Okuda, Toru Kuribayashi, En Yabe, Megumi Tsubota-Utsugi, Shinichi Omama, Toshiyuki Onoda, Masaki Ohsawa, Kuniaki Ogasawara, Fumitaka Tanaka, Koichi Asahi, Ryo Itabashi, Shigeki Ito, Yasushi Ishigaki, Fumiaki Takahashi, Makoto Koshiyama, Ryohei Sasaki, Daisuke Fujimaki, Nobuyuki Takanashi, Eri Takusari, Kiyomi Sakata, and Akira Okayama. 2021. "Association between Milk Intake and Incident Stroke among Japanese Community Dwellers: The Iwate-KENCO Study" Nutrients 13, no. 11: 3781. https://doi.org/10.3390/nu13113781

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