Next Article in Journal
Physiology and Inflammation Driven Pathophysiology of Iron Homeostasis—Mechanistic Insights into Anemia of Inflammation and Its Treatment
Previous Article in Journal
Dietary Supplement Use and Interactions with Tamoxifen and Aromatase Inhibitors in Breast Cancer Survivors Enrolled in Lifestyle Interventions
Article

Psychophysiological Effects of Lactobacillus plantarum PS128 in Patients with Major Depressive Disorder: A Preliminary 8-Week Open Trial

1
Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei 100, Taiwan
2
Department of Psychiatry, National Taiwan University Hospital, Taipei 100, Taiwan
3
Department of Psychiatry, Taipei Municipal Wan-Fang Hospital, Taipei Medical University, Taipei 116, Taiwan
4
Department of Psychiatry, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan
5
Institute of Biochemistry of Molecular Biology, National Yang-Ming University, Taipei 112, Taiwan
*
Authors to whom correspondence should be addressed.
Academic Editors: Leyuan Li, Malgorzata Muc-Wierzgon and Sandra Martin-Pelaez
Nutrients 2021, 13(11), 3731; https://doi.org/10.3390/nu13113731
Received: 26 September 2021 / Revised: 18 October 2021 / Accepted: 20 October 2021 / Published: 22 October 2021
(This article belongs to the Topic Probiotics, Prebiotics and Postbiotics in Human Health)
Recent studies have suggested that gut–brain axis may be one of the mechanisms of major depression disorder (MDD). The current study aimed to investigate the effects of Lactobacillus plantarum PS128 (PS128) on psychophysiology in patients with MDD. We recruited 11 patients with MDD and gave them PS128 for 8 weeks. We compared depression symptoms, serum markers of inflammation and gut permeability, and gut microbiota before and after 8-week intervention and also explored the correlations among symptoms, biomarkers, and gut microbiota. After 8-week PS128 intervention, scores of Hamilton Depression Rating Scale-17 and Depression and Somatic symptoms Scale significantly decreased. Serum levels of high sensitivity c-reactive protein, interluekin-6, and tumor necrosis factor-α, zonulin and intestinal fatty acid binding protein, and the composition of gut microbiota did not significantly change after 8-week PS128 intervention. However, we found changes of some genera were correlated with changes of symptoms and biomarkers. In conclusion, this is an open trial with small sample size and has several limitations. The results need to be verified by randomized, double-blind, placebo-controlled trial with larger sample size. View Full-Text
Keywords: probiotics; major depressive disorder; inflammation; gut permeability; microbiota probiotics; major depressive disorder; inflammation; gut permeability; microbiota
Show Figures

Figure 1

  • Supplementary File 1:

    ZIP-Document (ZIP, 640 KiB)

  • Externally hosted supplementary file 1
    Doi: 10.5281/zenodo.5528668
    Link: https://zenodo.org/record/5528668#.YVB8ny_RZ0s
    Description: Supplementary figure: S1─S3 (PDF, 600 KB). Figure S1: Flow chart of selection process, Figure S2: (A) Flow chart of correlation analysis between biomarkers and questionnaire scores, and (B) Correlations between inflammatory biomarkers and depressive assessments, Figure S3: Box plots of the relative abundance of six genera. Table S1: Top 4 phyla of relative abundance in each fecal sample (XLSX, 13 KB). Table S2: Average relative abundance of each phylum within each fecal group (XLSX, 12 KB). Table S3: 76 genera pairs with correlation coefficients and p-values (XLSX, 17 KB). Table S4: Significant correlations between the change of genera and biomarkers (XLSX, 12 KB). Table S5: Significant correlations between the change of genera and symptoms (XLSX, 12 KB).
MDPI and ACS Style

Chen, H.-M.; Kuo, P.-H.; Hsu, C.-Y.; Chiu, Y.-H.; Liu, Y.-W.; Lu, M.-L.; Chen, C.-H. Psychophysiological Effects of Lactobacillus plantarum PS128 in Patients with Major Depressive Disorder: A Preliminary 8-Week Open Trial. Nutrients 2021, 13, 3731. https://doi.org/10.3390/nu13113731

AMA Style

Chen H-M, Kuo P-H, Hsu C-Y, Chiu Y-H, Liu Y-W, Lu M-L, Chen C-H. Psychophysiological Effects of Lactobacillus plantarum PS128 in Patients with Major Depressive Disorder: A Preliminary 8-Week Open Trial. Nutrients. 2021; 13(11):3731. https://doi.org/10.3390/nu13113731

Chicago/Turabian Style

Chen, Hui-Mei, Po-Hsiu Kuo, Chia-Yueh Hsu, Yi-Hung Chiu, Yen-Wenn Liu, Mong-Liang Lu, and Chun-Hsin Chen. 2021. "Psychophysiological Effects of Lactobacillus plantarum PS128 in Patients with Major Depressive Disorder: A Preliminary 8-Week Open Trial" Nutrients 13, no. 11: 3731. https://doi.org/10.3390/nu13113731

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop