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Article

α1-Acid Glycoprotein and Dietary Intake in End-Stage Renal Disease Patients

1
Department of Physiology, Faculty of Medicine, Jagiellonian University Medical College, Grzegórzecka 16 St., 31-531 Kraków, Poland
2
Faculty of Medicine, Dietetics, Jagiellonian University Medical College, Anny 12 St., 31-008 Kraków, Poland
3
Chair of Clinical Biochemistry, Department of Diagnostics, Faculty of Medicine, Jagiellonian University Medical College, Skawińska 8 St., 31-066 Kraków, Poland
4
Department of Medical Diagnostics, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9 St., 30-688 Kraków, Poland
5
Chair and Department of Nephrology, Faculty of Medicine, Jagiellonian University Medical College, Jakubowskiego 2 St., 30-688 Kraków, Poland
*
Author to whom correspondence should be addressed.
Academic Editors: Yoshiyuki Morishita and Naoki Nakagawa
Nutrients 2021, 13(11), 3671; https://doi.org/10.3390/nu13113671
Received: 6 September 2021 / Revised: 12 October 2021 / Accepted: 13 October 2021 / Published: 20 October 2021
(This article belongs to the Special Issue Nutrients Influence on Kidney Diseases)
Management of end-stage renal disease (ESRD) patients requires monitoring each of the components of malnutrition–inflammation–atherosclerosis (MIA) syndrome. Restrictive diet can negatively affect nutritional status and inflammation. An acute-phase protein—α1-acid glycoprotein (AGP), has been associated with energy metabolism in animal and human studies. The aim of our study was to look for a relationship between serum AGP concentrations, laboratory parameters, and nutrient intake in ESRD patients. The study included 59 patients treated with maintenance hemodialysis. A 24 h recall assessed dietary intake during four non-consecutive days—two days in the post-summer period, and two post-winter. Selected laboratory tests were performed: complete blood count, serum iron, total iron biding capacity (TIBC) and unsaturated iron biding capacity (UIBC), vitamin D, AGP, C-reactive protein (CRP), albumin, prealbumin, and phosphate–calcium metabolism markers (intact parathyroid hormone, calcium, phosphate). Recorded dietary intake was highly deficient. A majority of patients did not meet recommended daily requirements for energy, protein, fiber, iron, magnesium, folate, and vitamin D. AGP correlated positively with CRP (R = 0.66), platelets (R = 0.29), and negatively with iron (R = −0.27) and TIBC (R = −0.30). AGP correlated negatively with the dietary intake of plant protein (R = −0.40), potassium (R = −0.27), copper (R = −0.30), vitamin B6 (R = −0.27), and folates (R = −0.27), p < 0.05. However, in multiple regression adjusted for confounders, only CRP was significantly associated with AGP. Our results indicate that in hemodialyzed patients, serum AGP is weakly associated with dietary intake of several nutrients, including plant protein. View Full-Text
Keywords: hemodialysis; end-stage kidney disease; malnutrition; dietary intake; α1-acid glycoprotein; appetite hemodialysis; end-stage kidney disease; malnutrition; dietary intake; α1-acid glycoprotein; appetite
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MDPI and ACS Style

Maraj, M.; Hetwer, P.; Kuśnierz-Cabala, B.; Maziarz, B.; Dumnicka, P.; Kuźniewski, M.; Ceranowicz, P. α1-Acid Glycoprotein and Dietary Intake in End-Stage Renal Disease Patients. Nutrients 2021, 13, 3671. https://doi.org/10.3390/nu13113671

AMA Style

Maraj M, Hetwer P, Kuśnierz-Cabala B, Maziarz B, Dumnicka P, Kuźniewski M, Ceranowicz P. α1-Acid Glycoprotein and Dietary Intake in End-Stage Renal Disease Patients. Nutrients. 2021; 13(11):3671. https://doi.org/10.3390/nu13113671

Chicago/Turabian Style

Maraj, Małgorzata, Paulina Hetwer, Beata Kuśnierz-Cabala, Barbara Maziarz, Paulina Dumnicka, Marek Kuźniewski, and Piotr Ceranowicz. 2021. "α1-Acid Glycoprotein and Dietary Intake in End-Stage Renal Disease Patients" Nutrients 13, no. 11: 3671. https://doi.org/10.3390/nu13113671

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