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Article

Obesity Modulates the Gut Microbiome in Triple-Negative Breast Cancer

1
School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
2
Department of Microbiology, Immunology and Genetics, University of North Texas Health Sciences Center, Fort Worth, TX 76107, USA
*
Author to whom correspondence should be addressed.
Co-first authors.
Academic Editor: Hiroto Narimatsu
Nutrients 2021, 13(10), 3656; https://doi.org/10.3390/nu13103656
Received: 6 September 2021 / Revised: 13 October 2021 / Accepted: 14 October 2021 / Published: 19 October 2021
Triple-negative breast cancer (TNBC) is an aggressive, molecularly heterogeneous subtype of breast cancer. Obesity is associated with increased incidence and worse prognosis in TNBC through various potential mechanisms. Recent evidence suggests that the gut microbiome plays a central role in the progression of cancer, and that imbalances or dysbiosis in the population of commensal microbiota can lead to inflammation and contribute to tumor progression. Obesity is characterized by low-grade inflammation, and gut dysbiosis is associated with obesity, chronic inflammation, and failure of cancer immunotherapy. However, the debate on what constitutes a “healthy” gut microbiome is ongoing, and the connection among the gut microbiome, obesity, and TNBC has not yet been addressed. This study aims to characterize the role of obesity in modulating the gut microbiome in a syngeneic mouse model of TNBC. 16S rRNA sequencing and metagenomic analyses were performed to analyze and annotate genus and taxonomic profiles. Our results suggest that obesity decreases alpha diversity in the gut microbiome. Metagenomic analysis revealed that obesity was the only significant factor explaining the similarity of the bacterial communities according to their taxonomic profiles. In contrast to the analysis of taxonomic profiles, the analysis of variation of functional profiles suggested that obesity status, tumor presence, and the obesity–tumor interaction were significant in explaining the variation of profiles, with obesity having the strongest correlation. The presence of tumor modified the profiles to a greater extent in obese than in lean animals. Further research is warranted to understand the impact of the gut microbiome on TNBC progression and immunotherapy. View Full-Text
Keywords: triple-negative breast cancer (TNBC); commensal microbiota; 16S rRNA sequencing; metagenomic analyses triple-negative breast cancer (TNBC); commensal microbiota; 16S rRNA sequencing; metagenomic analyses
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MDPI and ACS Style

Hossain, F.; Majumder, S.; David, J.; Bunnell, B.A.; Miele, L. Obesity Modulates the Gut Microbiome in Triple-Negative Breast Cancer. Nutrients 2021, 13, 3656. https://doi.org/10.3390/nu13103656

AMA Style

Hossain F, Majumder S, David J, Bunnell BA, Miele L. Obesity Modulates the Gut Microbiome in Triple-Negative Breast Cancer. Nutrients. 2021; 13(10):3656. https://doi.org/10.3390/nu13103656

Chicago/Turabian Style

Hossain, Fokhrul, Samarpan Majumder, Justin David, Bruce A. Bunnell, and Lucio Miele. 2021. "Obesity Modulates the Gut Microbiome in Triple-Negative Breast Cancer" Nutrients 13, no. 10: 3656. https://doi.org/10.3390/nu13103656

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