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Article

Association of Serum Phosphate with Low Handgrip Strength in Patients with Advanced Chronic Kidney Disease

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Division of Nephrology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan
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Division of Nephrology, Department of Internal Medicine, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung 81342, Taiwan
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School of Public Health, National Defense Medical Center, Taipei 114, Taiwan
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Department of Research and Development, National Defense Medical Center, Taipei 114, Taiwan
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Department of Biochemistry, National Defense Medical Center, Taipei 114, Taiwan
*
Author to whom correspondence should be addressed.
Academic Editor: Yugo Shibagaki
Nutrients 2021, 13(10), 3605; https://doi.org/10.3390/nu13103605
Received: 28 August 2021 / Revised: 29 September 2021 / Accepted: 13 October 2021 / Published: 14 October 2021
Muscle wasting and hyperphosphatemia are becoming increasingly prevalent in patients who exhibit a progressive decline in kidney function. However, the association between serum phosphate (Pi) level and sarcopenia in advanced chronic kidney disease (CKD) patients remains unclear. We compared the serum Pi levels between advanced CKD patients with (n = 51) and those without sarcopenia indicators (n = 83). Low appendicular skeletal muscle mass index (ASMI), low handgrip strength, and low gait speed were defined per the standards of the Asian Working Group for Sarcopenia. Mean serum Pi level was significantly higher in advanced CKD patients with sarcopenia indicators than those without sarcopenia indicators (3.88 ± 0.86 vs. 3.54 ± 0.73 mg/dL; p = 0.016). Univariate analysis indicated that serum Pi was negatively correlated with ASMI, handgrip strength, and gait speed. Multivariable analysis revealed that serum Pi was significantly associated with handgrip strength (standardized β = −0.168; p = 0.022) and this association persisted even after adjustments for potential confounders. The optimal serum Pi cutoff for predicting low handgrip strength was 3.65 mg/dL, with a sensitivity of 82.1% and specificity of 56.6%. In summary, low handgrip strength is common in advanced CKD patients and serum Pi level is negatively associated with handgrip strength. View Full-Text
Keywords: chronic kidney disease; hyperphosphatemia; sarcopenia; bioimpedance; handgrip strength chronic kidney disease; hyperphosphatemia; sarcopenia; bioimpedance; handgrip strength
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MDPI and ACS Style

Tsai, P.-H.; Yang, H.-C.; Lin, C.; Sung, C.-C.; Chu, P.; Hsu, Y.-J. Association of Serum Phosphate with Low Handgrip Strength in Patients with Advanced Chronic Kidney Disease. Nutrients 2021, 13, 3605. https://doi.org/10.3390/nu13103605

AMA Style

Tsai P-H, Yang H-C, Lin C, Sung C-C, Chu P, Hsu Y-J. Association of Serum Phosphate with Low Handgrip Strength in Patients with Advanced Chronic Kidney Disease. Nutrients. 2021; 13(10):3605. https://doi.org/10.3390/nu13103605

Chicago/Turabian Style

Tsai, Ping-Huang, Hsiu-Chien Yang, Chin Lin, Chih-Chien Sung, Pauling Chu, and Yu-Juei Hsu. 2021. "Association of Serum Phosphate with Low Handgrip Strength in Patients with Advanced Chronic Kidney Disease" Nutrients 13, no. 10: 3605. https://doi.org/10.3390/nu13103605

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