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Article

Zonarol Protected Liver from Methionine- and Choline-Deficient Diet-Induced Nonalcoholic Fatty Liver Disease in a Mouse Model

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Department of Pathology and Laboratory Medicine, Kanazawa Medical University, Ishikawa 920-0293, Japan
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Department of Medical Oncology, Kanazawa Medical University, Ishikawa 920-0293, Japan
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Department of Pathology, Kanazawa Medical University Hospital, Ishikawa 920-0293, Japan
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Laboratory of Nutraceuticals and Functional Foods Science, Graduate School of Marine Science and Technology, Tokyo 108-8477, Japan
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Department of Dermatology, Kanazawa Medical University, Ishikawa 920-0293, Japan
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College of Bioscience & Bioengineering, Hebei University of Science and Technology, Shijiazhuang 050018, China
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Department of Anti-Aging Food Research, School of Bioscience and Biotechnology, Tokyo University of Technology, Tokyo 192-0982, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Lindsay Brown
Nutrients 2021, 13(10), 3455; https://doi.org/10.3390/nu13103455
Received: 23 August 2021 / Revised: 27 September 2021 / Accepted: 27 September 2021 / Published: 29 September 2021
(This article belongs to the Section Protein)
Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases with no approved treatment. Zonarol, an extract from brown algae, has been proven to have anti-inflammatory and antioxidant effects. In this study, we investigated the role of zonarol in the progression of methionine- and choline-deficiency (MCD) diet-induced NAFLD in mice. After oral treatment with zonarol, a lighter body weight was observed in zonarol group (ZG) mice in comparison to control group (CG) mice. The NAFLD scores of ZG mice were lower than those of CG mice. Hepatic and serum lipid levels were also lower in ZG mice with the reduced expression of lipid metabolism-related factors. Furthermore, ZG mice showed less lipid deposition, less inflammatory cell infiltration and lower inflammatory cytokine levels in comparison to CG mice. Moreover, the numbers of 8-hydroxy-20-deoxyguanosine (8-OHdG)-positive hepatocytes and levels of hepatic and serum thiobarbituric acid reactive substances (TBARS) were significantly lower in comparison to CG mice. The expression levels of nuclear factor erythroid 2 related factor 2 (Nrf2), as well as its upstream and downstream molecules, changed in ZG mice. Zonarol could prevent the progression of NAFLD by decreasing inflammatory responses, oxidative stress and improving lipid metabolism. Meanwhile the Nrf2 pathway may play an important role in these effects. View Full-Text
Keywords: NAFLD; zonarol; Nrf2 NAFLD; zonarol; Nrf2
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MDPI and ACS Style

Han, J.; Guo, X.; Koyama, T.; Kawai, D.; Zhang, J.; Yamaguchi, R.; Zhou, X.; Motoo, Y.; Satoh, T.; Yamada, S. Zonarol Protected Liver from Methionine- and Choline-Deficient Diet-Induced Nonalcoholic Fatty Liver Disease in a Mouse Model. Nutrients 2021, 13, 3455. https://doi.org/10.3390/nu13103455

AMA Style

Han J, Guo X, Koyama T, Kawai D, Zhang J, Yamaguchi R, Zhou X, Motoo Y, Satoh T, Yamada S. Zonarol Protected Liver from Methionine- and Choline-Deficient Diet-Induced Nonalcoholic Fatty Liver Disease in a Mouse Model. Nutrients. 2021; 13(10):3455. https://doi.org/10.3390/nu13103455

Chicago/Turabian Style

Han, Jia, Xin Guo, Tomoyuki Koyama, Daichi Kawai, Jing Zhang, Reimon Yamaguchi, Xiaolei Zhou, Yoshiharu Motoo, Takumi Satoh, and Sohsuke Yamada. 2021. "Zonarol Protected Liver from Methionine- and Choline-Deficient Diet-Induced Nonalcoholic Fatty Liver Disease in a Mouse Model" Nutrients 13, no. 10: 3455. https://doi.org/10.3390/nu13103455

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