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The Fermented Soy Product ImmuBalanceTM Suppresses Airway Inflammation in a Murine Model of Asthma

Department of Respiratory Medicine, Graduate School of Medicine, Osaka City University, Osaka 545-8585, Japan
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Author to whom correspondence should be addressed.
Academic Editor: Lindsay Brown
Nutrients 2021, 13(10), 3380; https://doi.org/10.3390/nu13103380
Received: 1 September 2021 / Revised: 23 September 2021 / Accepted: 23 September 2021 / Published: 26 September 2021
(This article belongs to the Section Nutrition and Public Health)
The fermented soy product ImmuBalance contains many active ingredients and its beneficial effects on some allergic diseases have been reported. We hypothesized that ImmuBalance could have potential effects on airway inflammation in a murine model of asthma. Mice sensitized and challenged with ovalbumin developed airway inflammation. Bronchoalveolar lavage fluid was assessed for inflammatory cell counts and levels of cytokines. Lung tissues were examined for cell infiltration and mucus hypersecretion. Oral administration of ImmuBalance significantly inhibited ovalbumin-induced eosinophilic inflammation and decreased Th2 cytokine levels in bronchoalveolar lavage fluid (p < 0.05). In addition, lung histological analysis showed that ImmuBalance inhibited inflammatory cell infiltration and airway mucus production. Our findings suggest that supplementation with ImmuBalance may provide a novel strategy for the prevention or treatment of allergic airway inflammation. View Full-Text
Keywords: fermented soy product; asthma; eosinophilic inflammation; Th2 cytokines fermented soy product; asthma; eosinophilic inflammation; Th2 cytokines
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MDPI and ACS Style

Kadotani, H.; Asai, K.; Miyamoto, A.; Iwasaki, K.; Kawai, T.; Nishimura, M.; Tohda, M.; Okamoto, A.; Sato, K.; Yamada, K.; Ijiri, N.; Watanabe, T.; Kawaguchi, T. The Fermented Soy Product ImmuBalanceTM Suppresses Airway Inflammation in a Murine Model of Asthma. Nutrients 2021, 13, 3380. https://doi.org/10.3390/nu13103380

AMA Style

Kadotani H, Asai K, Miyamoto A, Iwasaki K, Kawai T, Nishimura M, Tohda M, Okamoto A, Sato K, Yamada K, Ijiri N, Watanabe T, Kawaguchi T. The Fermented Soy Product ImmuBalanceTM Suppresses Airway Inflammation in a Murine Model of Asthma. Nutrients. 2021; 13(10):3380. https://doi.org/10.3390/nu13103380

Chicago/Turabian Style

Kadotani, Hideaki, Kazuhisa Asai, Atsushi Miyamoto, Kohei Iwasaki, Takahiro Kawai, Misako Nishimura, Mitsunori Tohda, Atsuko Okamoto, Kanako Sato, Kazuhiro Yamada, Naoki Ijiri, Tetsuya Watanabe, and Tomoya Kawaguchi. 2021. "The Fermented Soy Product ImmuBalanceTM Suppresses Airway Inflammation in a Murine Model of Asthma" Nutrients 13, no. 10: 3380. https://doi.org/10.3390/nu13103380

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