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Effect of Ginseng Extracts on the Improvement of Osteopathic and Arthritis Symptoms in Women with Osteopenia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

1
Clinical Trial Center for Functional Foods, Jeonbuk National University Hospital, Jeonju 54907, Jeonbuk, Korea
2
Biomedical Research Institute, Jeonbuk National University Hospital, Jeonju 54907, Jeonbuk, Korea
3
Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, Rural Development Administration (RDA), Eumseong 27709, Chungbuk, Korea
4
Korea Food Research Institute, Wanju 55365, Jeonbuk, Korea
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Department of Food Science and Human Nutrition, Jeonbuk National University, 567 Baekje-daero, Jeonju 54896, Jeonbuk, Korea
6
Department of Orthopedic Surgery, Medical School, Jeonbuk National University, 567 Baekje-daero, Jeonju 54896, Jeonbuk, Korea
*
Author to whom correspondence should be addressed.
Nutrients 2021, 13(10), 3352; https://doi.org/10.3390/nu13103352
Received: 24 August 2021 / Revised: 17 September 2021 / Accepted: 21 September 2021 / Published: 24 September 2021
(This article belongs to the Section Phytochemicals and Human Health)
Ginsenosides are active compounds that are beneficial to bone metabolism and have anti-osteoporosis properties. However, very few clinical investigations have investigated the effect of ginseng extract (GE) on bone metabolism. This study aims to determine the effect of GE on improving bone metabolism and arthritis symptoms in postmenopausal women with osteopenia. A 12-week randomized, double-blind, placebo-controlled clinical trial was conducted. A total of 90 subjects were randomly divided into a placebo group, GE 1 g group, and GE 3 g group for 12 weeks based on the random 1:1:1 assignment to these three groups. The primary outcome is represented by bone metabolism indices consisting of serum osteocalcin (OC), urine deoxypyridinoline (DPD), and DPD/OC measurements. Secondary outcomes were serum CTX, NTX, Ca, P, BsALP, P1NP, OC/CTX ratio, and WOMAC index. The GE 3 g group had a significantly increased serum OC concentration. Similarly, the GE 3 g group showed a significant decrease in the DPD/OC ratio, representing bone resorption and bone formation. Moreover, among all the groups, the GE 3 g group demonstrated appreciable improvements in the WOMAC index scores. In women with osteopenia, intake of 3 g of GE per day over 12 weeks notably improved the knee arthritis symptoms with improvements in the OC concentration and ratios of bone formation indices like DPD/OC. View Full-Text
Keywords: ginseng extract; bone metabolism; osteopenia; arthritis symptoms; WOMAC ginseng extract; bone metabolism; osteopenia; arthritis symptoms; WOMAC
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MDPI and ACS Style

Jung, S.-J.; Oh, M.-R.; Lee, D.Y.; Lee, Y.-S.; Kim, G.-S.; Park, S.-H.; Han, S.-K.; Kim, Y.-O.; Yoon, S.-J.; Chae, S.-W. Effect of Ginseng Extracts on the Improvement of Osteopathic and Arthritis Symptoms in Women with Osteopenia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Nutrients 2021, 13, 3352. https://doi.org/10.3390/nu13103352

AMA Style

Jung S-J, Oh M-R, Lee DY, Lee Y-S, Kim G-S, Park S-H, Han S-K, Kim Y-O, Yoon S-J, Chae S-W. Effect of Ginseng Extracts on the Improvement of Osteopathic and Arthritis Symptoms in Women with Osteopenia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Nutrients. 2021; 13(10):3352. https://doi.org/10.3390/nu13103352

Chicago/Turabian Style

Jung, Su-Jin, Mi-Ra Oh, Dae Y. Lee, Young-Seob Lee, Geum-Soog Kim, Soo-Hyun Park, Soog-Kyoung Han, Young-Ock Kim, Sun-Jung Yoon, and Soo-Wan Chae. 2021. "Effect of Ginseng Extracts on the Improvement of Osteopathic and Arthritis Symptoms in Women with Osteopenia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial" Nutrients 13, no. 10: 3352. https://doi.org/10.3390/nu13103352

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