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Volume 13
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10.3390/nu13103346
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Article

Study of the Potential Hepatoprotective Effect of Myo-Inositol and Its Influence on Zebrafish Development

by
Tomasz Antonowski
1,*,
Karol Wiśniewski
2,
Piotr Podlasz
3,
Adam Osowski
1 and
Joanna Wojtkiewicz
1
1
Department of Human Physiology and Pathophysiology, School of Medicine, Collegium Medicum, University of Warmia and Mazury, 10-082 Olsztyn, Poland
2
Students’ Scientific Club of Pathophysiologists, Department of Human Physiology and Pathophysiology, School of Medicine, University of Warmia and Mazury, 10-082 Olsztyn, Poland
3
Department of Pathophysiology, Forensic Veterinary Medicine and Administration, Faculty of Veterinary Medicine, University of Warmia and Mazury, 10-719 Olsztyn, Poland
*
Author to whom correspondence should be addressed.
Nutrients 2021, 13(10), 3346; https://doi.org/10.3390/nu13103346
Submission received: 1 September 2021 / Revised: 19 September 2021 / Accepted: 20 September 2021 / Published: 24 September 2021
(This article belongs to the Special Issue Nutrition and Liver Disease)
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Abstract

Inositol is a natural substance found widely in plants. It is used in therapies for many medical cases. The aim of this study was to determine the toxicity of myo-inositol (MI) and to investigate its potential hepatoprotective character. In the first part of the study, zebrafish embryos were incubated with 5, 10, 20, 40, 60, 80, and 100 mg/mL MI. Endpoints such as survivability, hatching rate, malformation, and mobility were evaluated. Our results demonstrated that the high doses of MI lead to increased mortality and malformations and reduce the hatching rate in comparison to the control group. Moreover, low doses of this compound do not produce a negative effect on zebrafish and even have the ability to increase the hatching rate and mobility. In the second part of the study, the hepatoprotective effect of MI was tested. Zebrafish larvae from the line Tg (fabp10a:DsRed) were incubated for 24 h with 1% and 2% ethanol (EtOH), 5 mg/mL of MI with 1% EtOH, and 5 mg/mL of MI with 2% EtOH. No significant differences between the groups with EtOH and the group treated with EtOH with MI were observed. Our results suggest that MI has no positive benefits on hepatocytes of zebrafish larvae.
Keywords: myo-inositol; zebrafish; hepatoprotection; ethanol; alcoholic liver disease; acute liver damage myo-inositol; zebrafish; hepatoprotection; ethanol; alcoholic liver disease; acute liver damage

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MDPI and ACS Style

Antonowski, T.; Wiśniewski, K.; Podlasz, P.; Osowski, A.; Wojtkiewicz, J. Study of the Potential Hepatoprotective Effect of Myo-Inositol and Its Influence on Zebrafish Development. Nutrients 2021, 13, 3346. https://doi.org/10.3390/nu13103346

AMA Style

Antonowski T, Wiśniewski K, Podlasz P, Osowski A, Wojtkiewicz J. Study of the Potential Hepatoprotective Effect of Myo-Inositol and Its Influence on Zebrafish Development. Nutrients. 2021; 13(10):3346. https://doi.org/10.3390/nu13103346

Chicago/Turabian Style

Antonowski, Tomasz, Karol Wiśniewski, Piotr Podlasz, Adam Osowski, and Joanna Wojtkiewicz. 2021. "Study of the Potential Hepatoprotective Effect of Myo-Inositol and Its Influence on Zebrafish Development" Nutrients 13, no. 10: 3346. https://doi.org/10.3390/nu13103346

APA Style

Antonowski, T., Wiśniewski, K., Podlasz, P., Osowski, A., & Wojtkiewicz, J. (2021). Study of the Potential Hepatoprotective Effect of Myo-Inositol and Its Influence on Zebrafish Development. Nutrients, 13(10), 3346. https://doi.org/10.3390/nu13103346

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