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Article

The Impact of Short-Term Shark Liver Oil Supplementation on the Fatty Acid Composition of Erythrocyte Membranes

1
Department of Medical Biochemistry, Medical University of Lodz, Mazowiecka 6/8, 92-215 Lodz, Poland
2
Medical Committee of Polish Football Association, 02-366 Warsaw, Poland
3
Department of Infectious Diseases and Hepatology, Medical University of Lodz, 91-347 Lodz, Poland
*
Authors to whom correspondence should be addressed.
Academic Editors: Lillà Lionetti and Vincenzo Migliaccio
Nutrients 2021, 13(10), 3329; https://doi.org/10.3390/nu13103329
Received: 30 July 2021 / Revised: 14 September 2021 / Accepted: 17 September 2021 / Published: 23 September 2021
(This article belongs to the Special Issue Unsaturated Fatty Acids, Cellular Metabolism and Metabolic Diseases)
Fatty acid (FA) balance is strictly related to human health. The composition of fatty acids in lipid membranes seems to be influenced by diet. Shark liver oil (SLO) supplementation has been widely used recently in the prevention and treatment of human diseases. We analyzed the impact of short-term SLO supplementation on certain biochemical parameters and erythrocyte FA composition in a group of young healthy women. Our results showed that 6 weeks of SLO supplementation led to a significant decrease in C-reactive protein levels in sera and intracellular cholesterol levels in peripheral blood mononuclear cells. SLO supplementation caused a significant increase in the content of the polyunsaturated omega-3 FAs: docosahexaenoic acid, docosapentaenoic acid and α-linolenic acid. In the group of omega-6 FAs, we observed a significant elevation of arachidonic and dihomo-gamma-linoleic acid content. Due to these alterations, the omega-3 index increased significantly from 3.6% (before) to 4.2% (after supplementation). We also observed the impact of SLO supplementation on the membrane fluidity index. The ratio between saturated and unsaturated FAs decreased significantly from 13.1 to 9.9. In conclusion, our results show that even short-term SLO supplementation can improve human erythrocyte fatty acid composition and other parameters that may have health-promoting consequences. View Full-Text
Keywords: erythrocyte fatty acids; shark liver oil; PUFAs; omega-3; DHA; C-reactive protein; cholesterol; LDL-C; HDL-C erythrocyte fatty acids; shark liver oil; PUFAs; omega-3; DHA; C-reactive protein; cholesterol; LDL-C; HDL-C
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MDPI and ACS Style

Zakrzewska, K.; Oszajca, K.; Zep, W.; Piekarska, A.; Sidorkiewicz, M. The Impact of Short-Term Shark Liver Oil Supplementation on the Fatty Acid Composition of Erythrocyte Membranes. Nutrients 2021, 13, 3329. https://doi.org/10.3390/nu13103329

AMA Style

Zakrzewska K, Oszajca K, Zep W, Piekarska A, Sidorkiewicz M. The Impact of Short-Term Shark Liver Oil Supplementation on the Fatty Acid Composition of Erythrocyte Membranes. Nutrients. 2021; 13(10):3329. https://doi.org/10.3390/nu13103329

Chicago/Turabian Style

Zakrzewska, Katarzyna, Katarzyna Oszajca, Wojciech Zep, Anna Piekarska, and Malgorzata Sidorkiewicz. 2021. "The Impact of Short-Term Shark Liver Oil Supplementation on the Fatty Acid Composition of Erythrocyte Membranes" Nutrients 13, no. 10: 3329. https://doi.org/10.3390/nu13103329

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