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Clinical Significance of Analysis of Vitamin D Status in Various Diseases

1
Department of Bromatology, Poznan University of Medical Sciences, 42 Marcelińska Street, 60-354 Poznań, Poland
2
Department of Physical Pharmacy and Pharmacokinetics, Poznan University of Medical Sciences, 6 Święcickiego Street, 60-781 Poznań, Poland
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(9), 2788; https://doi.org/10.3390/nu12092788
Received: 29 July 2020 / Revised: 3 September 2020 / Accepted: 8 September 2020 / Published: 11 September 2020
(This article belongs to the Section Micronutrients and Human Health)
Vitamin D plays a role not only in the proper functioning of the skeletal system and the calcium-phosphate equilibrium, but also in the immune system, the cardiovascular system and the growth and division of cells. Although numerous studies have reported on the analysis of vitamin D status in various groups of patients, the clinical significance of measurements of vitamin D forms and metabolites remains ambiguous. This article reviews the reports analyzing the status of vitamin D in various chronic states. Particular attention is given to factors affecting measurement of vitamin D forms and metabolites. Relevant papers published during recent years were identified by an extensive PubMed search using appropriate keywords. Measurement of vitamin D status proved to be a useful tool in diagnosis and progression of metabolic syndrome, neurological disorders and cancer. High performance liquid chromatography coupled with tandem mass spectrometry has become the preferred method for analyzing the various forms and metabolites of vitamin D in biological fluids. Factors influencing vitamin D concentration, including socio-demographic and biochemical factors as well as the genetic polymorphism of the vitamin D receptor, along with vitamin D transporters and enzymes participating in vitamin D metabolism should be considered as potential confounders of the interpretation of plasma total 25(OH)D concentrations. View Full-Text
Keywords: calcidiol; calcitriol; liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS); vitamin D receptor; vitamin D status calcidiol; calcitriol; liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS); vitamin D receptor; vitamin D status
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MDPI and ACS Style

Kowalówka, M.; Główka, A.K.; Karaźniewicz-Łada, M.; Kosewski, G. Clinical Significance of Analysis of Vitamin D Status in Various Diseases. Nutrients 2020, 12, 2788. https://doi.org/10.3390/nu12092788

AMA Style

Kowalówka M, Główka AK, Karaźniewicz-Łada M, Kosewski G. Clinical Significance of Analysis of Vitamin D Status in Various Diseases. Nutrients. 2020; 12(9):2788. https://doi.org/10.3390/nu12092788

Chicago/Turabian Style

Kowalówka, Magdalena, Anna K. Główka, Marta Karaźniewicz-Łada, and Grzegorz Kosewski. 2020. "Clinical Significance of Analysis of Vitamin D Status in Various Diseases" Nutrients 12, no. 9: 2788. https://doi.org/10.3390/nu12092788

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