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Protective Effect of Spore Powder of Antrodia camphorata ATCC 200183 on CCl4-Induced Liver Fibrosis in Mice

1
School of Pharmaceutical Sciences, Jiangnan University, Wuxi 214122, China
2
National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi 214122, China
3
Jiangsu Engineering Research Center for Bioactive Products Processing Technology, Jiangnan University, Wuxi 214122, China
4
College of Food Science and Engineering, Yangzhou University, Yangzhou 225127, China
5
Key Laboratory of Industrial Biotechnology of Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(9), 2778; https://doi.org/10.3390/nu12092778
Received: 20 August 2020 / Revised: 6 September 2020 / Accepted: 9 September 2020 / Published: 11 September 2020
(This article belongs to the Section Clinical Nutrition)
Liver fibrosis is a pathological process with intrahepatic diffused deposition of the excess extracellular matrix, which leads to various chronic liver diseases. Drugs with high efficacy and low toxicity for liver fibrosis are still unavailable. Antrodia camphorata has antioxidant, antivirus, antitumor and anti-inflammation roles, and has been used to treat liver diseases in the population. However, the hepatoprotective effects of A. camphorata spores and the mechanisms behind it have not been investigated. In this study, we evaluate the hepatoprotective effect of spore powder of A. camphorata (SP, 100 mg/kg/day or 200 mg/kg/day) on carbon tetrachloride (CCl4)-induced liver fibrosis in mice. SP groups reduced serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities compared with the CCl4 group. SP also showed a decrease in hydroxyproline (Hyp) content in liver tissues. SP improved cell damage and reduced collagen deposition by H&E, Sirius red and Masson staining. Furthermore, SP down-regulated the mRNA levels of α-SMA and Col 1, and the protein expression of α-smooth muscle actin (α-SMA), collagen I (Col 1), tumor necrosis factor alpha (TNF-α), toll like receptor 4 (TLR4) and nuclear factor-Κb (NF-κB) p65. In summary, SP has an ameliorative effect on hepatic fibrosis, probably by inhibiting the activation of hepatic stellate cells, reducing the synthesis of extracellular matrix. View Full-Text
Keywords: Antrodia camphorata spore; liver damage; hepatic stellate cells; immunity Antrodia camphorata spore; liver damage; hepatic stellate cells; immunity
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MDPI and ACS Style

Ren, Y.; Li, H.-X.; Zhou, L.; Lu, Z.-M.; Shi, J.; Geng, Y.; Xu, Z.-H. Protective Effect of Spore Powder of Antrodia camphorata ATCC 200183 on CCl4-Induced Liver Fibrosis in Mice. Nutrients 2020, 12, 2778. https://doi.org/10.3390/nu12092778

AMA Style

Ren Y, Li H-X, Zhou L, Lu Z-M, Shi J, Geng Y, Xu Z-H. Protective Effect of Spore Powder of Antrodia camphorata ATCC 200183 on CCl4-Induced Liver Fibrosis in Mice. Nutrients. 2020; 12(9):2778. https://doi.org/10.3390/nu12092778

Chicago/Turabian Style

Ren, Yilin, Hua-Xiang Li, Lingxi Zhou, Zhen-Ming Lu, Jinsong Shi, Yan Geng, and Zheng-Hong Xu. 2020. "Protective Effect of Spore Powder of Antrodia camphorata ATCC 200183 on CCl4-Induced Liver Fibrosis in Mice" Nutrients 12, no. 9: 2778. https://doi.org/10.3390/nu12092778

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