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Article

Effects of Capsinoid Intake on Brown Adipose Tissue Vascular Density and Resting Energy Expenditure in Healthy, Middle-Aged Adults: A Randomized, Double-Blind, Placebo-Controlled Study

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Department of Sports Medicine for Health Promotion, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo 160-8402, Japan
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Department of Sport Sciences, Japan Institute of Sports Sciences, 3-15-1 Nishigaoka, Kita-ku, Tokyo 115-0056, Japan
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Ajinomoto Co., Inc., Institute of Food Sciences and Technologies, 1-1 Suzuki-cho, Kawasaki-ku, Kawasaki City, Kanagawa 210-8681, Japan
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Ajinomoto Co., Inc., Research Institute for Bioscience Products & Fine Chemicals, 1-1 Suzuki-cho, Kawasaki-ku, Kawasaki City, Kanagawa 210-8681, Japan
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Ajinomoto Co., Inc., Direct Marketing Department, 15-1, Kyobashi 1-chome, Chuo-ku, Tokyo 104-8315, Japan
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(9), 2676; https://doi.org/10.3390/nu12092676
Received: 30 July 2020 / Revised: 20 August 2020 / Accepted: 31 August 2020 / Published: 2 September 2020
(This article belongs to the Section Clinical Nutrition)
Capsinoids are some of the most promising ingredients to increase energy expenditure (EE) due to brown adipose tissue (BAT) activation. However, there is limited information regarding the effect of prolonged capsinoid ingestion (CI) on BAT activity and resting EE (REE) in healthy, middle-aged, normal to overweight subjects (Subhealthy) with distinct BAT characteristics. We examined the changes in BAT density (BAT-d), using near-infrared time-resolved spectroscopy, and REE/kg induced by daily CI. Forty Subhealthy [age, 43.8 (mean) years; BMI, 25.4 kg/m2] received either capsinoid (9 mg/day) or a placebo daily for 6 weeks in a double-blind design. Total hemoglobin concentration in the supraclavicular region ([total-Hb]sup), an indicator of BAT-d, and REE/kg were measured. The changes in post-intervention [total-Hb]sup were greater in the capsinoid group (CA-G) than in the placebo group (PL-G) [5.8 µM (+12.4%) versus 1.0 µM (+2.1%); p = 0.017]. There was a significant relationship between BAT-d and REE/kg; however, post-supplementation REE/kg was not significantly different between the two groups (p = 0.228). In the overweight subgroup, changes in REE/kg were greater in the CA-G than in the PL-G [0.6 cal/kg/min (+4.3%) versus −0.3 cal/kg/min (−2.1%); p = 0.021]. CI enhanced [total-Hb]sup, a reflection of BAT-d, showing a good correlation with REE in Subhealthy. View Full-Text
Keywords: capsinoids; dihydrocapsiate; energy expenditure; brown adipose tissue; middle-aged; near-infrared time-resolved spectroscopy capsinoids; dihydrocapsiate; energy expenditure; brown adipose tissue; middle-aged; near-infrared time-resolved spectroscopy
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MDPI and ACS Style

Fuse, S.; Endo, T.; Tanaka, R.; Kuroiwa, M.; Ando, A.; Kume, A.; Yamamoto, A.; Kuribayashi, K.; Somekawa, S.; Takeshita, M.; Hashimoto, M.; Kime, R.; Kurosawa, Y.; Hamaoka, T. Effects of Capsinoid Intake on Brown Adipose Tissue Vascular Density and Resting Energy Expenditure in Healthy, Middle-Aged Adults: A Randomized, Double-Blind, Placebo-Controlled Study. Nutrients 2020, 12, 2676. https://doi.org/10.3390/nu12092676

AMA Style

Fuse S, Endo T, Tanaka R, Kuroiwa M, Ando A, Kume A, Yamamoto A, Kuribayashi K, Somekawa S, Takeshita M, Hashimoto M, Kime R, Kurosawa Y, Hamaoka T. Effects of Capsinoid Intake on Brown Adipose Tissue Vascular Density and Resting Energy Expenditure in Healthy, Middle-Aged Adults: A Randomized, Double-Blind, Placebo-Controlled Study. Nutrients. 2020; 12(9):2676. https://doi.org/10.3390/nu12092676

Chicago/Turabian Style

Fuse, Sayuri; Endo, Tasuki; Tanaka, Riki; Kuroiwa, Miyuki; Ando, Akira; Kume, Ayami; Yamamoto, Akiko; Kuribayashi, Kanna; Somekawa, Shinji; Takeshita, Masamichi; Hashimoto, Masaki; Kime, Ryotaro; Kurosawa, Yuko; Hamaoka, Takafumi. 2020. "Effects of Capsinoid Intake on Brown Adipose Tissue Vascular Density and Resting Energy Expenditure in Healthy, Middle-Aged Adults: A Randomized, Double-Blind, Placebo-Controlled Study" Nutrients 12, no. 9: 2676. https://doi.org/10.3390/nu12092676

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