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The Crosstalk between Prostate Cancer and Microbiota Inflammation: Nutraceutical Products Are Useful to Balance This Interplay?

1
Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples “Federico II”, 80135 Naples, Italy
2
Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, 80135 Naples, Italy
3
Department of Health Science “V. Tiberio”, 86100 Campobasso, Italy
4
Department of Translational Medical Sciences, University of Campania Luigi Vanvitelli, 80135 Naples, Italy
5
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, 19122 PA, USA
6
Department of Experimental Medicine, University of Campania Luigi Vanvitelli, 80135 Naples, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally.
Nutrients 2020, 12(9), 2648; https://doi.org/10.3390/nu12092648
Received: 31 July 2020 / Revised: 25 August 2020 / Accepted: 26 August 2020 / Published: 31 August 2020
(This article belongs to the Special Issue Nutraceuticals and Human Health)
The human microbiota shows pivotal roles in urologic health and disease. Emerging studies indicate that gut and urinary microbiomes can impact several urological diseases, both benignant and malignant, acting particularly on prostate inflammation and prostate cancer. Indeed, the microbiota exerts its influence on prostate cancer initiation and/or progression mechanisms through the regulation of chronic inflammation, apoptotic processes, cytokines, and hormonal production in response to different pathogenic noxae. Additionally, therapies’ and drugs’ responses are influenced in their efficacy and tolerability by microbiota composition. Due to this complex potential interconnection between prostate cancer and microbiota, exploration and understanding of the involved relationships is pivotal to evaluate a potential therapeutic application in clinical practice. Several natural compounds, moreover, seem to have relevant effects, directly or mediated by microbiota, on urologic health, posing the human microbiota at the crossroad between prostatic inflammation and prostate cancer development. Here, we aim to analyze the most recent evidence regarding the possible crosstalk between prostate, microbiome, and inflammation. View Full-Text
Keywords: prostate cancer; microbiota; nutraceutical compounds prostate cancer; microbiota; nutraceutical compounds
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MDPI and ACS Style

Crocetto, F.; Boccellino, M.; Barone, B.; Di Zazzo, E.; Sciarra, A.; Galasso, G.; Settembre, G.; Quagliuolo, L.; Imbimbo, C.; Boffo, S.; Angelillo, I.F.; Di Domenico, M. The Crosstalk between Prostate Cancer and Microbiota Inflammation: Nutraceutical Products Are Useful to Balance This Interplay? Nutrients 2020, 12, 2648. https://doi.org/10.3390/nu12092648

AMA Style

Crocetto F, Boccellino M, Barone B, Di Zazzo E, Sciarra A, Galasso G, Settembre G, Quagliuolo L, Imbimbo C, Boffo S, Angelillo IF, Di Domenico M. The Crosstalk between Prostate Cancer and Microbiota Inflammation: Nutraceutical Products Are Useful to Balance This Interplay? Nutrients. 2020; 12(9):2648. https://doi.org/10.3390/nu12092648

Chicago/Turabian Style

Crocetto, Felice, Mariarosaria Boccellino, Biagio Barone, Erika Di Zazzo, Antonella Sciarra, Giovanni Galasso, Giuliana Settembre, Lucio Quagliuolo, Ciro Imbimbo, Silvia Boffo, Italo F. Angelillo, and Marina Di Domenico. 2020. "The Crosstalk between Prostate Cancer and Microbiota Inflammation: Nutraceutical Products Are Useful to Balance This Interplay?" Nutrients 12, no. 9: 2648. https://doi.org/10.3390/nu12092648

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