Next Article in Journal
TGR5 Signaling in Hepatic Metabolic Health
Next Article in Special Issue
The Crosstalk between Prostate Cancer and Microbiota Inflammation: Nutraceutical Products Are Useful to Balance This Interplay?
Previous Article in Journal
High Prevalence of Supplement Intake with a Concomitant Low Information Quality among Swiss Fitness Center Users
Previous Article in Special Issue
Lactoferrin from Bovine Milk: A Protective Companion for Life
Open AccessArticle

The Effect of Resveratrol or Curcumin on Head and Neck Cancer Cells Sensitivity to the Cytotoxic Effects of Cisplatin

1
Center of Immunology, Stefan S. Nicolau’ Institute of Virology, 030304 Bucharest, Romania
2
Department of Immunology, Victor Babeș’ National Institute of Pathology, 050096 Bucharest, Romania
3
Personal Genetics-Medical Genetics Center, Department of Cytogenetics, 010987 Bucharest, Romania
4
Department of Biotechnology, University of Agronomic Sciences and Veterinary Medicine of Bucharest, 011464 Βucharest, Romania
5
Biotechnology Department, National Institute for Chemistry and Petrochemistry R&D of Bucharest, 060021 Bucharest, Romania
6
Otorhinolaryngology and Head and Neck Surgery Department-University of Medicine and Pharmacy “Carol Davila”, 020021 Bucharest, Romania
7
Department of Cellular and Molecular Pathology, Stefan S. Nicolau Institute of Virology, 030304 Bucharest, Romania
*
Authors to whom correspondence should be addressed.
Equal contribution with the first author.
Nutrients 2020, 12(9), 2596; https://doi.org/10.3390/nu12092596
Received: 31 July 2020 / Revised: 20 August 2020 / Accepted: 21 August 2020 / Published: 26 August 2020
(This article belongs to the Special Issue Nutraceuticals and Human Health)
Natural compounds can modulate all three major phases of carcinogenesis. The role of the natural compounds such as resveratrol (RSV) and curcumin (CRM) in modulation of anticancer potential of platinum-based drugs (CisPt) is still a topic of considerable debate. In order to enhance head and neck cancer (HNSCC) cells’ sensitivity to the cytotoxic effects of CisPt combined treatments with RSV or CRM were used. The study aim was to evaluate how the RSV or CRM associated to CisPt treatment modulated some cellular processes such as proliferation, P21 gene expression, apoptotic process, and cell cycle development in HNSCC tumor cell line (PE/CA-PJ49) compared to a normal cell line (HUVEC). The results showed that RSV or CRM treatment affected the viability of tumor cells more than normal cells. These natural compounds act against proliferation and sustain the effects of cisplatin by cell cycle arrest, induction of apoptosis and amplification of P21 expression in tumor cells. In conclusion, using RSV or CRM as adjuvants in CisPt therapy might have a beneficial effect by supporting the effects induced by CisPt. View Full-Text
Keywords: resveratrol; curcumin; cisplatin; head and neck cancer; cell cycle; apoptosis resveratrol; curcumin; cisplatin; head and neck cancer; cell cycle; apoptosis
Show Figures

Figure 1

MDPI and ACS Style

Bostan, M.; Petrică-Matei, G.G.; Radu, N.; Hainarosie, R.; Stefanescu, C.D.; Diaconu, C.C.; Roman, V. The Effect of Resveratrol or Curcumin on Head and Neck Cancer Cells Sensitivity to the Cytotoxic Effects of Cisplatin. Nutrients 2020, 12, 2596. https://doi.org/10.3390/nu12092596

AMA Style

Bostan M, Petrică-Matei GG, Radu N, Hainarosie R, Stefanescu CD, Diaconu CC, Roman V. The Effect of Resveratrol or Curcumin on Head and Neck Cancer Cells Sensitivity to the Cytotoxic Effects of Cisplatin. Nutrients. 2020; 12(9):2596. https://doi.org/10.3390/nu12092596

Chicago/Turabian Style

Bostan, Marinela; Petrică-Matei, Georgiana G.; Radu, Nicoleta; Hainarosie, Razvan; Stefanescu, Cristian D.; Diaconu, Carmen C.; Roman, Viviana. 2020. "The Effect of Resveratrol or Curcumin on Head and Neck Cancer Cells Sensitivity to the Cytotoxic Effects of Cisplatin" Nutrients 12, no. 9: 2596. https://doi.org/10.3390/nu12092596

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop