Next Article in Journal
Cow and Human Milk-Derived Exosomes Ameliorate Colitis in DSS Murine Model
Next Article in Special Issue
Associations between Genotype–Diet Interactions and Weight Loss—A Systematic Review
Previous Article in Journal
Vitamin D Doses from Solar Ultraviolet and Dietary Intakes in Patients with Depression: Results of a Case-Control Study
Previous Article in Special Issue
Identification of Genetic Factors Underlying the Association between Sodium Intake Habits and Hypertension Risk
Open AccessArticle

Increased Risk of High Body Fat and Altered Lipid Metabolism Associated to Suboptimal Consumption of Vitamin A Is Modulated by Genetic Variants rs5888 (SCARB1), rs1800629 (UCP1) and rs659366 (UCP2)

by Sebastià Galmés 1,2,3,4, Andreu Palou 1,2,3,* and Francisca Serra 1,2,3,4
1
Laboratory of Molecular Biology, Nutrition and Biotechnology, NUO Group, Universitat de les Illes Balears, 07122 Palma, Spain
2
CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), 28029 Madrid, Spain
3
Institut d’Investigació Sanitària Illes Balears (IdISBa), 07120 Palma, Spain
4
Alimentómica S.L., Spin-off n.1 of the University of the Balearic Islands, 07121 Palma, Spain
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(9), 2588; https://doi.org/10.3390/nu12092588
Received: 13 May 2020 / Revised: 13 August 2020 / Accepted: 24 August 2020 / Published: 26 August 2020
(This article belongs to the Special Issue Precision Nutrition)
Obesity is characterized by an excessive body fat percentage (BF%). Animal and cell studies have shown benefits of vitamin A (VA) on BF% and lipid metabolism, but it is still controversial in humans. Furthermore, although some genetic variants may explain heterogeneity in VA plasma levels, their role in VA metabolic response is still scarcely characterized. This study was designed as a combination of an observational study involving 158 male subjects followed by a study with a well-balanced genotype–phenotype protocol, including in the design an ex vivo intervention study performed on isolated peripheral blood mononuclear cells (PBMCs) of the 41 former males. This is a strategy to accurately identify the delivery of Precision Nutrition recommendations to targeted subjects. The study assesses the influence of rs5888 (SCARB1), rs659366 (UCP2), and rs1800629 (UCP1) variants on higher BF% associated with suboptimal VA consumption and underlines the cellular mechanisms involved by analyzing basal and retinoic acid (RA) response on PBMC gene expression. Data show that male carriers with the major allele combinations and following suboptimal-VA diet show higher BF% (adjusted ANOVA test p-value = 0.006). Genotype–BF% interaction is observed on oxidative/inflammatory gene expression and also influences lipid related gene expression in response to RA. Data indicate that under suboptimal consumption of VA, carriers of VA responsive variants and with high-BF% show a gene expression profile consistent with an impaired basal metabolic state. The results show the relevance of consuming VA within the required amounts, its impact on metabolism and energy balance, and consequently, on men’s adiposity with a clear influence of genetic variants SCARB1, UCP2 and UCP1. View Full-Text
Keywords: personalized nutrition; dietary vitamin A; obesity; body fat; UCP; retinoic acid; PBMC personalized nutrition; dietary vitamin A; obesity; body fat; UCP; retinoic acid; PBMC
Show Figures

Figure 1

MDPI and ACS Style

Galmés, S.; Palou, A.; Serra, F. Increased Risk of High Body Fat and Altered Lipid Metabolism Associated to Suboptimal Consumption of Vitamin A Is Modulated by Genetic Variants rs5888 (SCARB1), rs1800629 (UCP1) and rs659366 (UCP2). Nutrients 2020, 12, 2588.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop