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Open AccessReview

Associations between Genotype–Diet Interactions and Weight Loss—A Systematic Review

1
Institute for Nutritional Medicine, University Hospital Klinikum rechts der Isar, School of Medicine, Technical University of Munich, 80992 Munich, Germany
2
Else Kröner-Fresenius-Center for Nutritional Medicine, School of Life Sciences, Technical University of Munich, 85354 Freising, Germany
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2020, 12(9), 2891; https://doi.org/10.3390/nu12092891
Received: 21 August 2020 / Revised: 17 September 2020 / Accepted: 18 September 2020 / Published: 22 September 2020
(This article belongs to the Special Issue Precision Nutrition)
Studies on the interactions between single nucleotide polymorphisms (SNPs) and macronutrient consumption on weight loss are rare and heterogeneous. This review aimed to conduct a systematic literature search to investigate genotype–diet interactions on weight loss. Four databases were searched with keywords on genetics, nutrition, and weight loss (PROSPERO: CRD42019139571). Articles in languages other than English and trials investigating special groups (e.g., pregnant women, people with severe diseases) were excluded. In total, 20,542 articles were identified, and, after removal of duplicates and further screening steps, 27 articles were included. Eligible articles were based on eight trials with 91 SNPs in 63 genetic loci. All articles examined the interaction between genotype and macronutrients (carbohydrates, fat, protein) on the extent of weight loss. However, in most cases, the interaction results were not significant and represented single findings that lack replication. The publications most frequently analyzed genotype–fat intake interaction on weight loss. Since the majority of interactions were not significant and not replicated, a final evaluation of the genotype–diet interactions on weight loss was not possible. In conclusion, no evidence was found that genotype–diet interaction is a main determinant of obesity treatment success, but this needs to be addressed in future studies. View Full-Text
Keywords: genetic variant; single nucleotide polymorphism; weight loss; nutrigenomics; dietary intervention; personalized nutrition genetic variant; single nucleotide polymorphism; weight loss; nutrigenomics; dietary intervention; personalized nutrition
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MDPI and ACS Style

Bayer, S.; Winkler, V.; Hauner, H.; Holzapfel, C. Associations between Genotype–Diet Interactions and Weight Loss—A Systematic Review. Nutrients 2020, 12, 2891. https://doi.org/10.3390/nu12092891

AMA Style

Bayer S, Winkler V, Hauner H, Holzapfel C. Associations between Genotype–Diet Interactions and Weight Loss—A Systematic Review. Nutrients. 2020; 12(9):2891. https://doi.org/10.3390/nu12092891

Chicago/Turabian Style

Bayer, Sandra; Winkler, Vincent; Hauner, Hans; Holzapfel, Christina. 2020. "Associations between Genotype–Diet Interactions and Weight Loss—A Systematic Review" Nutrients 12, no. 9: 2891. https://doi.org/10.3390/nu12092891

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