Effect of Maternal Diet and Milk Lipid Composition on the Infant Gut and Maternal Milk Microbiomes
Abstract
:1. Introduction
2. Materials and Methods
2.1. Participants and Sampling
2.2. Dietary Assessment
2.3. Analysis of Fatty Acids in Human Milk
2.4. Microbiome Composition Analysis
2.4.1. DNA Extraction
2.4.2. Amplicon Sequencing
2.4.3. Sequence Analysis
2.5. Statistical Analysis
3. Results
3.1. Multiple Core Genera Are Present in Both Human Milk and Infant Stool
3.2. An Individual Signature in Both Milk and Infant Gut Microbiomes Is Retained across Time
3.3. Maternal Milk Microbiome Is Affected by the Mother’s Nutrition
3.4. Fatty Acid Composition in Maternal Milk Directly Affects Maternal Microbiome
4. Discussion
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
References
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FFQ Nutrition Components | Bacteria Genus | p Value | False Discovery Rate | R |
---|---|---|---|---|
Total polyunsaturated fatty acids | Streptococcus | >0.001 | >0.001 | −0.734 |
Total monounsaturated fatty acids | Streptococcus | 0.001 | 0.098 | −0.668 |
Folic acid | Streptococcus | 0.001 | 0.098 | −0.669 |
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Babakobi, M.D.; Reshef, L.; Gihaz, S.; Belgorodsky, B.; Fishman, A.; Bujanover, Y.; Gophna, U. Effect of Maternal Diet and Milk Lipid Composition on the Infant Gut and Maternal Milk Microbiomes. Nutrients 2020, 12, 2539. https://doi.org/10.3390/nu12092539
Babakobi MD, Reshef L, Gihaz S, Belgorodsky B, Fishman A, Bujanover Y, Gophna U. Effect of Maternal Diet and Milk Lipid Composition on the Infant Gut and Maternal Milk Microbiomes. Nutrients. 2020; 12(9):2539. https://doi.org/10.3390/nu12092539
Chicago/Turabian StyleBabakobi, Michal Dayagi, Leah Reshef, Shalev Gihaz, Bogdan Belgorodsky, Ayelet Fishman, Yoram Bujanover, and Uri Gophna. 2020. "Effect of Maternal Diet and Milk Lipid Composition on the Infant Gut and Maternal Milk Microbiomes" Nutrients 12, no. 9: 2539. https://doi.org/10.3390/nu12092539