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Effects of Protein Supplementation Combined with Exercise Training on Muscle Mass and Function in Older Adults with Lower-Extremity Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Trials

1
School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei 100025, Taiwan
2
Department of Physical Medicine and Rehabilitation, Shuang Ho Hospital, Taipei Medical University, New Taipei City 235041, Taiwan
3
Physical Therapy Center, National Taiwan University Hospital, Taipei 100229, Taiwan
4
Department of Dietetics, National Taiwan University Hospital, Taipei 100225, Taiwan
5
School of Nutrition and Health Sciences, Taipei Medical University, Taipei 110301, Taiwan
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Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei 100025, Taiwan
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Department of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110301, Taiwan
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(8), 2422; https://doi.org/10.3390/nu12082422
Received: 14 July 2020 / Revised: 7 August 2020 / Accepted: 10 August 2020 / Published: 12 August 2020
Aging and osteoarthritis (OA) are associated with a high risk of muscle mass loss, which can lead to physical disability. This study investigated the effectiveness of protein supplementation combined with exercise training (PS + ET) in improving muscle mass and functional outcomes in older adults with lower-limb OA. A comprehensive search of online databases was performed to identify randomized controlled trials (RCTs) on the effectiveness of PS + ET in older adults with hip or knee OA. Meta-analysis and risk of bias assessment of the included RCTs were conducted. Six RCTs were included in this systemic review; they had a median (range/total) Physiotherapy Evidence Database (PEDro) score of 7 (6–9) out of 10, respectively. Five RCTs that enrolled patients who underwent total joint replacement were included in this meta-analysis. The PS + ET group exhibited significant improvements in muscle mass (standard mean difference [SMD] = 1.13, p < 0.00001), pain (SMD = 1.36, p < 0.00001), and muscle strength (SMD = 0.44, p = 0.04). Our findings suggest that PS + ET improves muscle mass, muscle strength, and functional outcomes and reduces pain in older adults with lower-limb OA, particularly in those who have undergone total joint replacement. View Full-Text
Keywords: osteoarthritis; sarcopenia; arthroplasty; protein supplement; exercise training; muscle mass; physical function osteoarthritis; sarcopenia; arthroplasty; protein supplement; exercise training; muscle mass; physical function
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Liao, C.-D.; Wu, Y.-T.; Tsauo, J.-Y.; Chen, P.-R.; Tu, Y.-K.; Chen, H.-C.; Liou, T.-H. Effects of Protein Supplementation Combined with Exercise Training on Muscle Mass and Function in Older Adults with Lower-Extremity Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Trials. Nutrients 2020, 12, 2422.

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