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Open AccessArticle

Effect of Co-Administration of Panax ginseng and Brassica oleracea on Postmenopausal Osteoporosis in Ovariectomized Mice

1
Laboratory for Leukocyte Signaling Research, Department of Pharmacology, Inha University School of Medicine, Incheon 22212, Korea
2
Laboratory of Fundamental Research, Korea Ginseng Research Institute, Korea Ginseng Corporation, Daejeon 34128, Korea
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(8), 2415; https://doi.org/10.3390/nu12082415
Received: 6 July 2020 / Revised: 7 August 2020 / Accepted: 10 August 2020 / Published: 12 August 2020
(This article belongs to the Special Issue Osteoporosis Prevention and Nutrition)
Postmenopausal osteoporosis is a common disorder resulting from increased osteoclastic activity. To determine the effect of Panax ginseng on postmenopausal osteoporosis, ovariectomized (OVX) mice were treated with 500 mg/kg/day P. ginseng extract (Pg) alone or in combination with hot water extract of Brassica oleracea (Bo) daily for 10 weeks, and the effect of the treatments on OVX-induced bone loss was examined. Bone weight, bone mineral density (BMD), osteoclast (OC) formation, OC marker expression, and biochemical parameters in blood were determined. OVX significantly increased body weight and decreased bone weight compared with those in the Sham group (p < 0.01). Pg or Bo alone did not affect OVX-induced bone loss, but a combination of Pg and Bo (Pg:Bo) recovered bone weight. The bones of OVX mice showed lower BMD than that of Sham mice, and the Pg:Bo = 3:1 restored the decreased BMD. Single treatment with Pg or Bo did not alter OC formation; however, the Pg:Bo = 3:1 inhibited OC formation. In addition, Pg and Bo lowered the OVX-induced elevation in blood glucose level. Thus, we suggest that Pg in combination with proper materials, such as Bo, might be a potential candidate treatment with minimal side effects protect against postmenopausal osteoporosis. View Full-Text
Keywords: Panax ginseng; Brassica oleracea; postmenopausal osteoporosis; ovariectomy; bone mineral density Panax ginseng; Brassica oleracea; postmenopausal osteoporosis; ovariectomy; bone mineral density
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Kang, I.S.; Agidigbi, T.S.; Kwon, Y.M.; Kim, D.-G.; Kim, R.I.; In, G.; Lee, M.-H.; Kim, C. Effect of Co-Administration of Panax ginseng and Brassica oleracea on Postmenopausal Osteoporosis in Ovariectomized Mice. Nutrients 2020, 12, 2415.

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