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Open AccessArticle

Hydroxytyrosol as a Promising Ally in the Treatment of Fibromyalgia

Department of Experimental Biology, University of Jaén, 23071 Jaén, Spain
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Nutrients 2020, 12(8), 2386; https://doi.org/10.3390/nu12082386
Received: 30 June 2020 / Revised: 29 July 2020 / Accepted: 7 August 2020 / Published: 9 August 2020
(This article belongs to the Special Issue Dietary Antioxidants for Human Health)
Fibromyalgia (FM) is a chronic and highly disabling syndrome, which is still underdiagnosed, with controversial treatment. Although its aetiology is unknown, a number of studies have pointed to the involvement of altered mitochondrial metabolism, increased oxidative stress and inflammation. The intake of extra virgin olive oil, and particularly of one of its phenolic compounds, hydroxytyrosol (HT), has proven to be protective in terms of redox homeostatic balance and the reduction of inflammation. In this context, using a proteomic approach with nanoscale liquid chromatography coupled to tandem mass spectrometry, the present study analysed: (i) Changes in the proteome of dermal fibroblasts from a patient with FM versus a healthy control, and (ii) the effect of the treatment with a nutritional relevant dose of HT. Our results unveiled that fibroblast from FM show a differential expression in proteins involved in the turnover of extracellular matrix and oxidative metabolism that could explain the inflammatory status of these patients. Moreover, a number of these proteins results normalized by the treatment with HT. In conclusion, our results support that an HT-enriched diet could be highly beneficial in the management of FM. View Full-Text
Keywords: fibromyalgia; hydroxytyrosol; extracellular matrix; energy metabolism fibromyalgia; hydroxytyrosol; extracellular matrix; energy metabolism
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Ramírez-Tejero, J.A.; Martínez-Lara, E.; Peinado, M.Á.; del Moral, M.L.; Siles, E. Hydroxytyrosol as a Promising Ally in the Treatment of Fibromyalgia. Nutrients 2020, 12, 2386.

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