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Article

Extracts of Phellinus linteus, Bamboo (Sasa senanensis) Leaf and Chaga Mushroom (Inonotus obliquus) Exhibit Antitumor Activity through Activating Innate Immunity

by 1,*,†, 1,2,†, 1, 2 and 3,4,*
1
Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto 860-0082, Japan
2
Department of Applied Microbial Technology, Faculty of Biotechnology and Life Science, Sojo University, Kumamoto 860-0082, Japan
3
Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan
4
Biodynamics Research Foundation, Kumamoto 862-0954, Japan
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this paper.
Nutrients 2020, 12(8), 2279; https://doi.org/10.3390/nu12082279
Received: 3 July 2020 / Revised: 23 July 2020 / Accepted: 27 July 2020 / Published: 29 July 2020
(This article belongs to the Special Issue Immune Function and Nutrient Supplementation)
Natural products have attracted great interest for some time as alternative methods against cancers by fulfilling immunomodulating properties. In this study, we investigated the activity of hot water extracts (120 °C, >30 min) of Phellinus linteus, fresh leaves of Kumaizasa bamboo and Chaga mushroom which we called MeshimaMax, for cancer prevention and treatment by using different solid tumor models. In the implanted mouse sarcoma S180 tumor, MeshimaMax treatment significantly inhibited tumor growth when it was applied at the early stage of tumor inoculation. The effect was further confirmed by using carcinogen induced tumors, i.e., azoxymethane (AOM)/dextran sulfate sodium (DSS) induced mouse colon cancer and 7,12-dimethylbenz anthracene (DMBA) induced rat breast cancer. In both cases the occurrences of tumors were remarkably suppressed by administration of MeshimaMax which consists of three components above. More importantly, when MeshimaMax was combined with an anticancer chemotherapeutic drug, the therapeutic effect was remarkably improved. In vitro studies showed that when MeshimaMax was applied to mouse macrophage RAW264.7 cells the phagocytosis of macrophages was significantly activated, which was evaluated by using living yeast cells as well as synthetic nanoparticles. A cytotoxicity assay showed the 50% inhibitory concentration (IC50) was higher than 1 mg/mL and normal cells were 2–3 times more tolerant to MeshimaMax than cancer cells. These findings suggest the potential application of MeshimaMax for cancer prevention and as supplement regimen for anticancer chemotherapy, probably functioning through activation of innate immunity, which may benefit cancer patients as an alternative supplement. View Full-Text
Keywords: Phellinus linteus; Kumaizasa; bamboo leaf; Chaga mushroom; cancer prevention; macrophage; immunostimulation; innate immunity; supplement Phellinus linteus; Kumaizasa; bamboo leaf; Chaga mushroom; cancer prevention; macrophage; immunostimulation; innate immunity; supplement
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MDPI and ACS Style

Fang, J.; Gao, S.; Islam, R.; Teramoto, Y.; Maeda, H. Extracts of Phellinus linteus, Bamboo (Sasa senanensis) Leaf and Chaga Mushroom (Inonotus obliquus) Exhibit Antitumor Activity through Activating Innate Immunity. Nutrients 2020, 12, 2279. https://doi.org/10.3390/nu12082279

AMA Style

Fang J, Gao S, Islam R, Teramoto Y, Maeda H. Extracts of Phellinus linteus, Bamboo (Sasa senanensis) Leaf and Chaga Mushroom (Inonotus obliquus) Exhibit Antitumor Activity through Activating Innate Immunity. Nutrients. 2020; 12(8):2279. https://doi.org/10.3390/nu12082279

Chicago/Turabian Style

Fang, Jun, Shanghui Gao, Rayhanul Islam, Yuji Teramoto, and Hiroshi Maeda. 2020. "Extracts of Phellinus linteus, Bamboo (Sasa senanensis) Leaf and Chaga Mushroom (Inonotus obliquus) Exhibit Antitumor Activity through Activating Innate Immunity" Nutrients 12, no. 8: 2279. https://doi.org/10.3390/nu12082279

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