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Open AccessArticle

Dietary Oligofructose Alone or in Combination with 2′-Fucosyllactose Differentially Improves Recognition Memory and Hippocampal mRNA Expression

1
Piglet Nutrition and Cognition Laboratory, Department of Animal Sciences, University of Illinois, Urbana, IL 61801, USA
2
Neuroscience Program, University of Illinois, Urbana, IL 61801, USA
3
Nestlé Research, 1000 Lausanne, Switzerland
4
Nestlé Product Technology Center Nutrition, 3510 Konolfingen, Switzerland
5
Department of Food Science and Human Nutrition, University of Illinois, Urbana, IL 61801, USA
6
Division of Nutritional Sciences, University of Illinois, Urbana, IL 61801, USA
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(7), 2131; https://doi.org/10.3390/nu12072131
Received: 23 June 2020 / Revised: 12 July 2020 / Accepted: 14 July 2020 / Published: 17 July 2020
Mounting evidence suggests that dietary oligosaccharides promote brain development. This study assessed the capacity of oligofructose (OF) alone or in combination with 2′-fucosyllactose (2′-FL) to alter recognition memory, structural brain development, and hippocampal gene expression. Beginning on postnatal day (PND) 2, male pigs received one of three milk replacers formulated to contain OF, OF + 2′-FL, or no oligosaccharides (CON). Pigs were tested on the novel object recognition task using delays of 1 or 48 h at PND 22. At PND 32–33, magnetic resonance imaging (MRI) procedures were used to assess structural brain development and hippocampal tissue was collected for analysis of mRNA expression. Pigs that consumed the OF diet demonstrated increased recognition memory after a 1 h delay, whereas those consuming diets containing OF + 2′-FL displayed increased recognition memory after a 48 h delay. Pigs fed OF or OF + 2′-FL exhibited a larger relative volume of the olfactory bulbs compared with CON pigs. Provision of OF or OF + 2′-FL altered gene expression related to dopaminergic, GABAergic, cholinergic, cell adhesion, and chromatin remodeling processes. Collectively, these data indicate that dietary OF and OF + 2′-FL differentially improve cognitive performance and affect olfactory bulb structural development and hippocampal gene expression. View Full-Text
Keywords: prebiotics; milk; pig; brain; cognition; neuroimaging; human milk oligosaccharides; infant; nutrition prebiotics; milk; pig; brain; cognition; neuroimaging; human milk oligosaccharides; infant; nutrition
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MDPI and ACS Style

Fleming, S.A.; Mudd, A.T.; Hauser, J.; Yan, J.; Metairon, S.; Steiner, P.; Donovan, S.M.; Dilger, R.N. Dietary Oligofructose Alone or in Combination with 2′-Fucosyllactose Differentially Improves Recognition Memory and Hippocampal mRNA Expression. Nutrients 2020, 12, 2131. https://doi.org/10.3390/nu12072131

AMA Style

Fleming SA, Mudd AT, Hauser J, Yan J, Metairon S, Steiner P, Donovan SM, Dilger RN. Dietary Oligofructose Alone or in Combination with 2′-Fucosyllactose Differentially Improves Recognition Memory and Hippocampal mRNA Expression. Nutrients. 2020; 12(7):2131. https://doi.org/10.3390/nu12072131

Chicago/Turabian Style

Fleming, Stephen A.; Mudd, Austin T.; Hauser, Jonas; Yan, Jian; Metairon, Sylviane; Steiner, Pascal; Donovan, Sharon M.; Dilger, Ryan N. 2020. "Dietary Oligofructose Alone or in Combination with 2′-Fucosyllactose Differentially Improves Recognition Memory and Hippocampal mRNA Expression" Nutrients 12, no. 7: 2131. https://doi.org/10.3390/nu12072131

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