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Open AccessArticle

Omega-3 Phospholipids from Krill Oil Enhance Intestinal Fatty Acid Oxidation More Effectively than Omega-3 Triacylglycerols in High-Fat Diet-Fed Obese Mice

1
Laboratory of Adipose Tissue Biology, Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic
2
Human and Animal Physiology, Wageningen University, 6708 WD Wageningen, The Netherlands
3
Laboratory of Epithelial Physiology, Institute of Physiology of the Czech Academy of Sciences, 14220 Prague, Czech Republic
4
Proteomics Core Facility, Faculty of Science, Charles University, Division BIOCEV, 25250 Vestec, Czech Republic
*
Authors to whom correspondence should be addressed.
Nutrients 2020, 12(7), 2037; https://doi.org/10.3390/nu12072037
Received: 27 May 2020 / Revised: 3 July 2020 / Accepted: 6 July 2020 / Published: 9 July 2020
(This article belongs to the Special Issue Nutrient Targeting of Intestinal Mucosa Wall to Modulate Metabolism)
Antisteatotic effects of omega-3 fatty acids (Omega-3) in obese rodents seem to vary depending on the lipid form of their administration. Whether these effects could reflect changes in intestinal metabolism is unknown. Here, we compare Omega-3-containing phospholipids (krill oil; ω3PL-H) and triacylglycerols (ω3TG) in terms of their effects on morphology, gene expression and fatty acid (FA) oxidation in the small intestine. Male C57BL/6N mice were fed for 8 weeks with a high-fat diet (HFD) alone or supplemented with 30 mg/g diet of ω3TG or ω3PL-H. Omega-3 index, reflecting the bioavailability of Omega-3, reached 12.5% and 7.5% in the ω3PL-H and ω3TG groups, respectively. Compared to HFD mice, ω3PL-H but not ω3TG animals had lower body weight gain (−40%), mesenteric adipose tissue (−43%), and hepatic lipid content (−64%). The highest number and expression level of regulated intestinal genes was observed in ω3PL-H mice. The expression of FA ω-oxidation genes was enhanced in both Omega-3-supplemented groups, but gene expression within the FA β-oxidation pathway and functional palmitate oxidation in the proximal ileum was significantly increased only in ω3PL-H mice. In conclusion, enhanced intestinal FA oxidation could contribute to the strong antisteatotic effects of Omega-3 when administered as phospholipids to dietary obese mice. View Full-Text
Keywords: krill oil; Omega-3 phospholipids; high-fat diet; Omega-3 index; small intestine krill oil; Omega-3 phospholipids; high-fat diet; Omega-3 index; small intestine
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MDPI and ACS Style

Kroupova, P.; van Schothorst, E.M.; Keijer, J.; Bunschoten, A.; Vodicka, M.; Irodenko, I.; Oseeva, M.; Zacek, P.; Kopecky, J.; Rossmeisl, M.; Horakova, O. Omega-3 Phospholipids from Krill Oil Enhance Intestinal Fatty Acid Oxidation More Effectively than Omega-3 Triacylglycerols in High-Fat Diet-Fed Obese Mice. Nutrients 2020, 12, 2037. https://doi.org/10.3390/nu12072037

AMA Style

Kroupova P, van Schothorst EM, Keijer J, Bunschoten A, Vodicka M, Irodenko I, Oseeva M, Zacek P, Kopecky J, Rossmeisl M, Horakova O. Omega-3 Phospholipids from Krill Oil Enhance Intestinal Fatty Acid Oxidation More Effectively than Omega-3 Triacylglycerols in High-Fat Diet-Fed Obese Mice. Nutrients. 2020; 12(7):2037. https://doi.org/10.3390/nu12072037

Chicago/Turabian Style

Kroupova, Petra; van Schothorst, Evert M.; Keijer, Jaap; Bunschoten, Annelies; Vodicka, Martin; Irodenko, Ilaria; Oseeva, Marina; Zacek, Petr; Kopecky, Jan; Rossmeisl, Martin; Horakova, Olga. 2020. "Omega-3 Phospholipids from Krill Oil Enhance Intestinal Fatty Acid Oxidation More Effectively than Omega-3 Triacylglycerols in High-Fat Diet-Fed Obese Mice" Nutrients 12, no. 7: 2037. https://doi.org/10.3390/nu12072037

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