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Effects of Dietary Fibres on Acute Indomethacin-Induced Intestinal Hyperpermeability in the Elderly: A Randomised Placebo Controlled Parallel Clinical Trial

1
School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Södra Grev Rosengatan 32, 703 62 Örebro, Sweden
2
Genetic Analysis AS, Kabelgata 8, 0580 Oslo, Norway
3
Department of Biomedical and Clinical Sciences, Linköping University, 581 85 Linköping, Sweden
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(7), 1954; https://doi.org/10.3390/nu12071954
Received: 25 May 2020 / Revised: 18 June 2020 / Accepted: 28 June 2020 / Published: 30 June 2020
(This article belongs to the Special Issue Role of Prebiotics and Probiotics in Health and Disease)
The effect of dietary fibres on intestinal barrier function has not been well studied, especially in the elderly. We aimed to investigate the potential of the dietary fibres oat β-glucan and wheat arabinoxylan to strengthen the intestinal barrier function and counteract acute non-steroid anti-inflammatory drug (indomethacin)-induced hyperpermeability in the elderly. A general population of elderly subjects (≥65 years, n = 49) was randomised to a daily supplementation (12g/day) of oat β-glucan, arabinoxylan or placebo (maltodextrin) for six weeks. The primary outcome was change in acute indomethacin-induced intestinal permeability from baseline, assessed by an in vivo multi-sugar permeability test. Secondary outcomes were changes from baseline in: gut microbiota composition, systemic inflammatory status and self-reported health. Despite a majority of the study population (85%) showing a habitual fibre intake below the recommendation, no significant effects on acute indomethacin-induced intestinal hyperpermeability in vivo or gut microbiota composition were observed after six weeks intervention with either dietary fibre, compared to placebo. View Full-Text
Keywords: dietary fibres; prebiotics; intestinal permeability; NSAIDs; clinical trial; elderly; intestinal barrier function; gut health dietary fibres; prebiotics; intestinal permeability; NSAIDs; clinical trial; elderly; intestinal barrier function; gut health
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MDPI and ACS Style

Ganda Mall, J.-P.; Fart, F.; Sabet, J.A.; Lindqvist, C.M.; Nestestog, R.; Hegge, F.T.; Keita, Å.V.; Brummer, R.J.; Schoultz, I. Effects of Dietary Fibres on Acute Indomethacin-Induced Intestinal Hyperpermeability in the Elderly: A Randomised Placebo Controlled Parallel Clinical Trial. Nutrients 2020, 12, 1954. https://doi.org/10.3390/nu12071954

AMA Style

Ganda Mall J-P, Fart F, Sabet JA, Lindqvist CM, Nestestog R, Hegge FT, Keita ÅV, Brummer RJ, Schoultz I. Effects of Dietary Fibres on Acute Indomethacin-Induced Intestinal Hyperpermeability in the Elderly: A Randomised Placebo Controlled Parallel Clinical Trial. Nutrients. 2020; 12(7):1954. https://doi.org/10.3390/nu12071954

Chicago/Turabian Style

Ganda Mall, John-Peter, Frida Fart, Julia A. Sabet, Carl M. Lindqvist, Ragnhild Nestestog, Finn T. Hegge, Åsa V. Keita, Robert J. Brummer, and Ida Schoultz. 2020. "Effects of Dietary Fibres on Acute Indomethacin-Induced Intestinal Hyperpermeability in the Elderly: A Randomised Placebo Controlled Parallel Clinical Trial" Nutrients 12, no. 7: 1954. https://doi.org/10.3390/nu12071954

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