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Role of the Proportional Intake of Fortified Mother’s Own Milk in the Weight Gain Pattern of Their Very-Preterm-Born Infants
Open AccessArticle

Factors in Early Feeding Practices That May Influence Growth and the Challenges That Arise in Growth Outcomes Research

Connecticut Children’s, Division of Neonatology, Hartford, CT 06106, USA
Department of Pediatrics, University of Connecticut School of Medicine, Farmington, CT 06032, USA
Department of Pediatrics, Yale School of Medicine, New Haven, CT 06443, USA
Author to whom correspondence should be addressed.
Nutrients 2020, 12(7), 1939;
Received: 1 June 2020 / Revised: 19 June 2020 / Accepted: 23 June 2020 / Published: 30 June 2020
(This article belongs to the Special Issue Fortification of Human Milk in the Neonatal Intensive Care Unit)
Growth in preterm infants is associated with improved outcomes during both the initial hospitalization and long-term. A single center investigation evaluated preterm infant in-hospital growth trajectory and how it related to early nutritional practices as a way to identify areas for quality improvement. Infants born <34 weeks’ gestational age and with discharge at or prior to 40 weeks’ gestational age were included and were divided into quartiles based on their change in weight z-score through hospitalization. Early nutritional factors were compared between the lowest and highest growth quartiles. Although the highest growth quartile experienced less days of parenteral nutrition and higher enteral caloric density in the first week, as the data was analyzed, potential statistical pitfalls became apparent. Therefore, the aim of this study was to investigate selection bias and cohort effect related to both the inclusion criteria for this cohort as well as the inherent challenges in comparison of preterm infant growth trajectories by standard fetal growth charts. View Full-Text
Keywords: preterm; growth; z-score; nutrition preterm; growth; z-score; nutrition
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Fabrizio, V.; Shabanova, V.; Taylor, S.N. Factors in Early Feeding Practices That May Influence Growth and the Challenges That Arise in Growth Outcomes Research. Nutrients 2020, 12, 1939.

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