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Improvement of Learning and Memory in Senescence-Accelerated Mice by S-Allylcysteine in Mature Garlic Extract

1
United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan
2
Research and Development Department, Ichimaru Pharcos Co., Ltd., 318-1 Asagi, Gifu 501-0475, Japan
3
School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(6), 1834; https://doi.org/10.3390/nu12061834
Received: 16 May 2020 / Revised: 13 June 2020 / Accepted: 17 June 2020 / Published: 19 June 2020
(This article belongs to the Section Phytochemicals and Human Health)
S-allylcysteine (SAC), a major thioallyl compound contained in mature garlic extract (MGE), is known to be a neuroactive compound. This study was designed to investigate the effects of SAC on primary cultured hippocampal neurons and cognitively impaired senescence-accelerated mice prone 10 (SAMP10). Treatment of these neurons with MGE or SAC significantly increased the total neurite length and number of dendrites. SAMP10 mice fed MGE or SAC showed a significant improvement in memory dysfunction in pharmacological behavioral analyses. The decrease of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor, N-methyl-d-aspartate (NMDA) receptor, and phosphorylated α-calcium/calmodulin-dependent protein kinase II (CaMKII) in the hippocampal tissue of SAMP10 mice fed MGE or SAC was significantly suppressed, especially in the MGE-fed group. These findings suggest that SAC positively contributes to learning and memory formation, having a beneficial effect on brain function. In addition, multiple components (aside from SAC) contained in MGE could be useful for improving cognitive function by acting as neurotrophic factors. View Full-Text
Keywords: S-allylcysteine (SAC); mature garlic extract (MGE); hippocampal neuron; senescence-accelerated mice; memory; cognitive function S-allylcysteine (SAC); mature garlic extract (MGE); hippocampal neuron; senescence-accelerated mice; memory; cognitive function
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MDPI and ACS Style

Hashimoto, M.; Nakai, T.; Masutani, T.; Unno, K.; Akao, Y. Improvement of Learning and Memory in Senescence-Accelerated Mice by S-Allylcysteine in Mature Garlic Extract. Nutrients 2020, 12, 1834. https://doi.org/10.3390/nu12061834

AMA Style

Hashimoto M, Nakai T, Masutani T, Unno K, Akao Y. Improvement of Learning and Memory in Senescence-Accelerated Mice by S-Allylcysteine in Mature Garlic Extract. Nutrients. 2020; 12(6):1834. https://doi.org/10.3390/nu12061834

Chicago/Turabian Style

Hashimoto, Masakazu, Tsuyoshi Nakai, Teruaki Masutani, Keiko Unno, and Yukihiro Akao. 2020. "Improvement of Learning and Memory in Senescence-Accelerated Mice by S-Allylcysteine in Mature Garlic Extract" Nutrients 12, no. 6: 1834. https://doi.org/10.3390/nu12061834

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