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Article

Dietary Red Meat Adversely Affects Disease Severity in a Pig Model of DSS-Induced Colitis Despite Reduction in Colonic Pro-Inflammatory Gene Expression

1
Department of Animal Science, Aarhus University, DK-8830 Tjele, Denmark
2
Innovation Fund Denmark, DK-8000 Aarhus C, Denmark
3
Focused Research Unit for Molecular Diagnostics and Clinical Research, IRS-Centre Soenderjylland, University Hospital of Southern Denmark, DK-6200 Aabenraa, Denmark
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(6), 1728; https://doi.org/10.3390/nu12061728
Received: 4 May 2020 / Revised: 28 May 2020 / Accepted: 5 June 2020 / Published: 9 June 2020
(This article belongs to the Special Issue Nutrition and Inflammatory Bowel Disease (IBD))
Diet plays a substantial role in the pathogenesis and management of ulcerative colitis (UC), and epidemiologic studies indicate an association between red meat intake and increased risk of UC development. Therefore, we evaluated the effect of a red meat diet on dextran sulfate sodium (DSS)-induced colitis in pigs. Weaned pigs (42 days old) were fed either a control diet or a diet substituted with 15% minced, cooked and dried beef from experimental day 0 to 14. From day 14 to 18, half of the pigs on each diet received a daily oral dose of DSS. Dietary red meat aggravated the severity of colitis based on clinical signs of disease (negative performance score) and histopathological parameters in the colon such as erosion/ulceration and the overall inflammation score but no negative effects were observed on systemic health or small intestinal permeability. Importantly, dietary meat also caused a potential beneficial reduction in the colonic expression of the pro-inflammatory cytokines IL-17A and IL-6, the pro-inflammatory enzyme PTGS2 and in the chemokine IL-8. The present study emphasizes the potential of diet to modulate mucosal inflammation and that a red meat diet might be a risk factor for the development of inflammatory bowel disease. View Full-Text
Keywords: diet; inflammatory bowel disease; porcine; dextran sulfate sodium; inflammation; histology; gene expression diet; inflammatory bowel disease; porcine; dextran sulfate sodium; inflammation; histology; gene expression
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MDPI and ACS Style

Nielsen, T.S.; Fredborg, M.; Theil, P.K.; Yue, Y.; Bruhn, L.V.; Andersen, V.; Purup, S. Dietary Red Meat Adversely Affects Disease Severity in a Pig Model of DSS-Induced Colitis Despite Reduction in Colonic Pro-Inflammatory Gene Expression. Nutrients 2020, 12, 1728. https://doi.org/10.3390/nu12061728

AMA Style

Nielsen TS, Fredborg M, Theil PK, Yue Y, Bruhn LV, Andersen V, Purup S. Dietary Red Meat Adversely Affects Disease Severity in a Pig Model of DSS-Induced Colitis Despite Reduction in Colonic Pro-Inflammatory Gene Expression. Nutrients. 2020; 12(6):1728. https://doi.org/10.3390/nu12061728

Chicago/Turabian Style

Nielsen, Tina S., Marlene Fredborg, Peter K. Theil, Yuan Yue, Lærke V. Bruhn, Vibeke Andersen, and Stig Purup. 2020. "Dietary Red Meat Adversely Affects Disease Severity in a Pig Model of DSS-Induced Colitis Despite Reduction in Colonic Pro-Inflammatory Gene Expression" Nutrients 12, no. 6: 1728. https://doi.org/10.3390/nu12061728

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