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Open AccessArticle

The Effect of a 2-Week Red Ginseng Supplementation on Food Efficiency and Energy Metabolism in Mice

by Hyejung Hwang 1, Jisu Kim 1 and Kiwon Lim 1,2,*
1
Physical Activity and Performance Institute (PAPI), Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Korea
2
Department of Physical Education, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Korea
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(6), 1726; https://doi.org/10.3390/nu12061726
Received: 29 April 2020 / Revised: 28 May 2020 / Accepted: 5 June 2020 / Published: 9 June 2020
(This article belongs to the Section Nutrition and Metabolism)
Red ginseng (RG) ingestion reportedly affects body weight, food intake, and fat accumulation reduction. It also induces changes in energy metabolism regulation and glycemic control. Previously, 2-week RG ingestion with endurance training was found to enhance fat oxidation during exercise. However, such effects on energy metabolism and the expression of mRNAs related to energy substrate utilization in resting mice (untrained mice) are still unclear. Here, we determined the effect of RG on energy metabolism and substrate utilization in untrained male mice. Twenty-four mice were separated into an RG group that received a daily dosage of 1 g/kg RG for 2 weeks, and a control (CON). Energy expenditure, blood and tissue glycogen levels, and expression of mRNAs related to energy substrate utilization in muscles were measured before and 2 weeks after treatment. Total food intake was significantly lower in the RG than in the CON group (p < 0.05), but final body weights did not differ. Carbohydrate and fat oxidation over 24 h did not change in either group. There were no significant differences in gastrocnemius GLUT4, MCT1, MCT4, FAT/CD36, and CPT1b mRNA levels between groups. Thus, the effects of RG ingested during rest differ from the effects of RG ingestion in combination with endurance exercise; administering RG to untrained mice for 2 weeks did not change body weight and energy metabolism. Therefore, future studies should consider examining the RG ingestion period and dosage for body weight control and improving energy metabolism. View Full-Text
Keywords: red ginseng; body weight; energy metabolism; FAT/CD36; GLUT4 red ginseng; body weight; energy metabolism; FAT/CD36; GLUT4
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Hwang, H.; Kim, J.; Lim, K. The Effect of a 2-Week Red Ginseng Supplementation on Food Efficiency and Energy Metabolism in Mice. Nutrients 2020, 12, 1726.

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