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Association of Dietary Acid Load with the Prevalence of Metabolic Syndrome among Participants in Baseline Survey of the Japan Multi-Institutional Collaborative Cohort Study

1
Department of Preventive Medicine, Tokushima University Graduate School of Biomedical Sciences, Tokushima 770-8503, Japan
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Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan
3
Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga 849-8501, Japan
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Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan
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School of Health Sciences, Faculty of Medicine, Kagoshima University, Kagoshima 890-8544, Japan
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Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
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Department of Public Health, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan
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Laboratory of Public Health, Division of Nutritional Sciences, School of Food and Nutritional Sciences, University of Shizuoka, Shizuoka 422-8526, Japan
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Department of Public Health, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan
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Department of Public Health, Faculty of Medicine, Kindai University, Osaka-Sayama, Osaka 589-8511, Japan
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Department of Comprehensive General Internal Medicine, Faculty of Medical Sciences, Kyushu University Graduate School of Medicine, Fukuoka 812-8582, Japan
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Department of General Internal Medicine, Kyushu University Hospital, Fukuoka 812-8582, Japan
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Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan
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Department of Cancer Epidemiology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan
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Cancer Prevention Center, Chiba Cancer Center Research Institute, Chiba 260-8717, Japan
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(6), 1605; https://doi.org/10.3390/nu12061605
Received: 3 April 2020 / Revised: 20 May 2020 / Accepted: 27 May 2020 / Published: 29 May 2020
(This article belongs to the Section Nutritional Epidemiology)
The association between dietary acid load and metabolic syndrome (MetS) has not been fully investigated. A cross-sectional study was performed on 14,042 men and 14,105 women (aged 35–69 years) who participated in a baseline survey of the Japan Multi-Institutional Collaborative Cohort study. Dietary acid load was assessed using the net-endogenous-acid-production (NEAP) score that is closely correlated with the rate of renal net acid excretion. MetS was diagnosed according to the Joint Interim Statement Criteria of 2009 using body-mass index instead of waist circumference. After adjusting for potential confounders, higher NEAP scores were associated with a significantly increased odds ratio (OR) of MetS, obesity, high blood pressure, and high fasting blood glucose. These associations remained significant after further adjustment for carbohydrate intake or two nutrient-pattern scores significantly associated with MetS. After adjustment for fiber, iron, potassium, and vitamin pattern scores, the OR of MetS for the highest quartile of NEAP scores, relative to the lowest quartile, was 1.25 (95% confidence interval 1.12–1.39). There was no significant interaction between sex, age, or body-mass index and NEAP. Higher dietary acid load was associated with a higher prevalence of MetS and several of its components, independently of carbohydrate intake or nutrient patterns. View Full-Text
Keywords: dietary acid load; metabolic syndrome; net endogenous acid production; cross-sectional study dietary acid load; metabolic syndrome; net endogenous acid production; cross-sectional study
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Arisawa, K.; Katsuura-Kamano, S.; Uemura, H.; Van Tien, N.; Hishida, A.; Tamura, T.; Kubo, Y.; Tsukamoto, M.; Tanaka, K.; Hara, M.; Takezaki, T.; Nishimoto, D.; Koyama, T.; Ozaki, E.; Suzuki, S.; Nishiyama, T.; Kuriki, K.; Kadota, A.; Takashima, N.; Ikezaki, H.; Murata, M.; Oze, I.; Matsuo, K.; Mikami, H.; Nakamura, Y.; Takeuchi, K.; Wakai, K. Association of Dietary Acid Load with the Prevalence of Metabolic Syndrome among Participants in Baseline Survey of the Japan Multi-Institutional Collaborative Cohort Study. Nutrients 2020, 12, 1605.

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