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Immunomodulatory Effects of Vitamin D in Thyroid Diseases

1
Department of Translational Medicine, University of Piemonte Orientale UPO, 28100 Novara, Italy
2
Division of General Medicine, S. Giuseppe Hospital, I.R.C.C.S. Istituto Auxologico Italiano, 28824 Verbania, Italy
3
Department of Health Sciences, University of Piemonte Orientale UPO, 28100 Novara, Italy
4
Division of Endocrinology, University Hospital “Maggiore della Carità”, 28100 Novara, Italy
5
Division of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, 10126 Turin, Italy
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(5), 1444; https://doi.org/10.3390/nu12051444
Received: 19 April 2020 / Revised: 12 May 2020 / Accepted: 14 May 2020 / Published: 16 May 2020
(This article belongs to the Special Issue Vitamin D on Immune Function)
Vitamin D is a secosteroid with a pleiotropic role in multiple physiological processes. Besides the well-known activity on bone homeostasis, recent studies suggested a peculiar role of vitamin D in different non-skeletal pathways, including a key role in the modulation of immune responses. Recent evidences demonstrated that vitamin D acts on innate and adaptative immunity and seems to exert an immunomodulating action on autoimmune diseases and cancers. Several studies demonstrated a relationship between vitamin D deficiency, autoimmune thyroid disorders, and thyroid cancer. This review aims to summarize the evidences on the immunomodulatory effect of vitamin D on thyroid diseases. View Full-Text
Keywords: vitamin D; immune system; thyroid autoimmunity; thyroid cancer vitamin D; immune system; thyroid autoimmunity; thyroid cancer
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Mele, C.; Caputo, M.; Bisceglia, A.; Samà, M.T.; Zavattaro, M.; Aimaretti, G.; Pagano, L.; Prodam, F.; Marzullo, P. Immunomodulatory Effects of Vitamin D in Thyroid Diseases. Nutrients 2020, 12, 1444.

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