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Immunomodulatory Effects of Vitamin D in Thyroid Diseases

Department of Translational Medicine, University of Piemonte Orientale UPO, 28100 Novara, Italy
Division of General Medicine, S. Giuseppe Hospital, I.R.C.C.S. Istituto Auxologico Italiano, 28824 Verbania, Italy
Department of Health Sciences, University of Piemonte Orientale UPO, 28100 Novara, Italy
Division of Endocrinology, University Hospital “Maggiore della Carità”, 28100 Novara, Italy
Division of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, 10126 Turin, Italy
Author to whom correspondence should be addressed.
Nutrients 2020, 12(5), 1444;
Received: 19 April 2020 / Revised: 12 May 2020 / Accepted: 14 May 2020 / Published: 16 May 2020
(This article belongs to the Special Issue Vitamin D on Immune Function)
Vitamin D is a secosteroid with a pleiotropic role in multiple physiological processes. Besides the well-known activity on bone homeostasis, recent studies suggested a peculiar role of vitamin D in different non-skeletal pathways, including a key role in the modulation of immune responses. Recent evidences demonstrated that vitamin D acts on innate and adaptative immunity and seems to exert an immunomodulating action on autoimmune diseases and cancers. Several studies demonstrated a relationship between vitamin D deficiency, autoimmune thyroid disorders, and thyroid cancer. This review aims to summarize the evidences on the immunomodulatory effect of vitamin D on thyroid diseases. View Full-Text
Keywords: vitamin D; immune system; thyroid autoimmunity; thyroid cancer vitamin D; immune system; thyroid autoimmunity; thyroid cancer
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Mele, C.; Caputo, M.; Bisceglia, A.; Samà, M.T.; Zavattaro, M.; Aimaretti, G.; Pagano, L.; Prodam, F.; Marzullo, P. Immunomodulatory Effects of Vitamin D in Thyroid Diseases. Nutrients 2020, 12, 1444.

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