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Open AccessArticle

β2 Adrenergic Regulation of the Phagocytic and Microbicide Capacity of Circulating Monocytes: Influence of Obesity and Exercise

1
Grupo de Investigación en Inmunofisiología, Departamento de Enfermería, Facultad de Medicina, Universidad de Extremadura, 06071 Badajoz, Spain
2
Instituto Universitario de Investigación Biosanitaria de Extremadura (INUBE), 06071 Badajoz, Spain
3
Grupo de Investigación en Inmunofisiología, Departamento de Enfermería, Centro Universitario de Plasencia, Universidad de Extremadura, 10600 Plasencia, Spain
4
Grupo de Investigación en Inmunofisiología, Departamento de Fisiología, Facultad de Ciencias, Universidad de Extremadura, 06071 Badajoz, Spain
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2020, 12(5), 1438; https://doi.org/10.3390/nu12051438
Received: 19 March 2020 / Revised: 8 May 2020 / Accepted: 13 May 2020 / Published: 16 May 2020
(This article belongs to the Special Issue Nutrition, Exercise and Human Health)
Obese individuals present anomalous immune/inflammatory responses with dysregulations in neuroendocrine responses and immune/stress feedback mechanisms. In this context, exercise and β2 adrenergic activation present monocyte-mediated anti-inflammatory effects that are modulated by obesity. However, these anti-inflammatory effects could immunocompromise the monocyte-mediated innate response against a pathogen challenge. Thus, the objective of this work was to evaluate the effect of obesity, and exercise in this condition, on the β2 adrenergic regulation of the phagocytic and microbicide capacity of circulating monocytes. C57BL/6J mice were allocated to different sedentary or exercised, lean or obese groups. Obese mice showed a lower monocyte-mediated innate response than that of lean mice. Globally, selective β2 adrenergic receptor agonist terbutaline decreased the innate response of monocytes from lean and obese sedentary animals, whereas exercise stimulated it. Exercise modulates β2 adrenergic regulation of the innate response in lean and obese animals, with a global stimulatory or neutral effect, thus abolishing the inhibitory effect of terbutaline occurring in sedentary animals. These effects cannot be explained only by changes in the surface expression of toll-like receptors. Therefore, in general, terbutaline does not hinder the effects of regular exercise, but regular exercise does abolish the effects of terbutaline in sedentary individuals. View Full-Text
Keywords: β2 adrenergic receptors; terbutaline; obesity; exercise; monocytes; phagocytosis; microbicide activity; toll-like receptors; TLR4; TLR2 β2 adrenergic receptors; terbutaline; obesity; exercise; monocytes; phagocytosis; microbicide activity; toll-like receptors; TLR4; TLR2
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MDPI and ACS Style

Gálvez, I.; Martín-Cordero, L.; Hinchado, M.D.; Ortega, E. β2 Adrenergic Regulation of the Phagocytic and Microbicide Capacity of Circulating Monocytes: Influence of Obesity and Exercise. Nutrients 2020, 12, 1438. https://doi.org/10.3390/nu12051438

AMA Style

Gálvez I, Martín-Cordero L, Hinchado MD, Ortega E. β2 Adrenergic Regulation of the Phagocytic and Microbicide Capacity of Circulating Monocytes: Influence of Obesity and Exercise. Nutrients. 2020; 12(5):1438. https://doi.org/10.3390/nu12051438

Chicago/Turabian Style

Gálvez, Isabel; Martín-Cordero, Leticia; Hinchado, María D.; Ortega, Eduardo. 2020. "β2 Adrenergic Regulation of the Phagocytic and Microbicide Capacity of Circulating Monocytes: Influence of Obesity and Exercise" Nutrients 12, no. 5: 1438. https://doi.org/10.3390/nu12051438

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