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Hydrolyzed Chicken Extract (ProBeptigen®) on Cognitive Function in Healthy Middle-Aged People: A Randomized Double-Blind Trial

Department of Neurology, Shuang-Ho Hospital, Taipei Medical University, New Taipei 235, Taiwan
School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan
Research Center for Brain and Consciousness, Taipei Medical University, Taipei 235, Taiwan
Department of Family Medicine, Wanfang Hospital, Taipei 116, Taiwan
Research and Development, BRAND’S Suntory Asia, Singapore 138623, Singapore
PhD Program for Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei 110, Taiwan
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2020, 12(5), 1362;
Received: 25 March 2020 / Revised: 7 May 2020 / Accepted: 9 May 2020 / Published: 10 May 2020
(This article belongs to the Section Macronutrients and Human Health)
Cognitive decline is an important issue of global public health. Cognitive aging might begin at middle adulthood, the period particularly vulnerable to stress in lifespan. Essence of chicken (EOC) has consistently demonstrated its beneficial effects on various cognitive domains as nutritional supplementation. This study primarily aimed to examine the cognitive enhancement effects of ProBeptigen® (previously named CMI-168), hydrolyzed peptides extracted from EOC, in healthy middle-aged people under mild stress. Ninety healthy subjects were randomly assigned into the ProBeptigen® or placebo group for eight weeks. Neurocognitive assessment, event-related potentials (ERPs), and blood tests were conducted before, during, and after the treatment. The ProBeptigen® group outperformed placebo group on Logical Memory subtests of Wechsler Memory Scale-third edition (WMS-III) and Spatial Working Memory task in the Cambridge Neuropsychological Test Automated Battery (CANTAB). The anti-inflammatory effects of ProBeptigen® in humans were also confirmed, with progressively declining high-sensitivity C-reactive protein (hs-CRP) levels. Regular dietary supplementation of ProBeptigen® is suggested to improve verbal short- and long-term memory as well as spatial working memory, and reduce inflammation in middle-aged healthy individuals with stress. The effects of ProBeptigen® on cognition warrant further investigation. (NCT03612752) View Full-Text
Keywords: dietary supplements; cognitive decline; essence of chicken dietary supplements; cognitive decline; essence of chicken
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Wu, D.; Yang, C.-C.; Chen, K.-Y.; Lin, Y.-C.; Wu, P.-J.; Hsieh, P.-H.; Nakao, Y.; Ow, M.Y.L.; Hsieh, Y.-C.; Hu, C.-J. Hydrolyzed Chicken Extract (ProBeptigen®) on Cognitive Function in Healthy Middle-Aged People: A Randomized Double-Blind Trial. Nutrients 2020, 12, 1362.

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