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Open AccessArticle

Eckol from Ecklonia cava Suppresses Immunoglobulin E-mediated Mast Cell Activation and Passive Cutaneous Anaphylaxis in Mice (Running Title: Anti-Allergic Activity of Ecklonia cava)

1
Department of Food Technology and Nutrition, Chonnam National University, Yeosu 59626, Korea
2
National Marine Biodiversity Institute of Korea, 75, Jangsan-ro 101 gil, Janghang-eup, Seocheon 33662, Korea
3
Department of Marine Life Science, Jeju National University, Jeju 63243, Korea
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Department of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University, Jeju 63243, Korea
5
Naturetech, 29-8, Yongjeong-gil, Chopyeong-myeon, Jincheon-gun, Chungbuk 27858, Korea
6
Fisheries Science Institute, Chonnam National University, Daehak-Ro, Yeosu 59626, Korea
7
Department of Marine Bio-Food Sciences, Chonnam National University, Yeosu 59626, Korea
*
Authors to whom correspondence should be addressed.
Nutrients 2020, 12(5), 1361; https://doi.org/10.3390/nu12051361
Received: 15 February 2020 / Revised: 4 May 2020 / Accepted: 4 May 2020 / Published: 9 May 2020
(This article belongs to the Section Phytochemicals and Human Health)
Eckol, a precursor compound belonging to the dibenzo-1,4-dioxin class of phlorotannins, is a phloroglucinol derivative that exerts various activities. In the present study, we investigated the antiallergic effects of eckol isolated from the marine brown algae, Ecklonia cava using immunoglobulin E (IgE)/bovine serum albumin (BSA)-stimulated mouse bone marrow-derived cultured mast cells (BMCMC) and a mouse model of anaphylaxis. Eckol inhibited IgE/BSA-induced BMCMC degranulation by reducing β-hexosaminidase release. A flow cytometric analysis revealed that eckol decreases FcεRI expression on cell surface and IgE binding to the FcεRI in BMCMC. Moreover, eckol suppressed the production of the cytokines, interleukin (IL)-4, IL-5, IL-6, and IL-13 and the chemokine, thymus activation-regulated chemokine (TARC) by downregulating, IκB-α degradation and NF-κB nuclear translocation. Furthermore, it attenuated the passive cutaneous anaphylactic reaction induced by IgE/BSA-stimulation in the ear of BALB/c mice. These results suggest that eckol is a potential therapeutic candidate for the prevention and treatment of allergic disorders. View Full-Text
Keywords: Ecklonia cava; Eckol; immunoglobulin E; bone marrow-derived cultured mast cells; passive cutaneous anaphylaxis Ecklonia cava; Eckol; immunoglobulin E; bone marrow-derived cultured mast cells; passive cutaneous anaphylaxis
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Han, E.J.; Kim, H.-S.; Sanjeewa, K.; Herath, K.; Jeon, Y.-J.; Jee, Y.; Lee, J.; Kim, T.; Shim, S.-Y.; Ahn, G. Eckol from Ecklonia cava Suppresses Immunoglobulin E-mediated Mast Cell Activation and Passive Cutaneous Anaphylaxis in Mice (Running Title: Anti-Allergic Activity of Ecklonia cava). Nutrients 2020, 12, 1361.

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