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Nutrients
Volume 12
Issue 5
10.3390/nu12051359
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Brief Report

25-Hydroxyvitamin D Concentrations Are Lower in Patients with Positive PCR for SARS-CoV-2

by
Antonio D’Avolio
1,*,
Valeria Avataneo
1,
Alessandra Manca
1,
Jessica Cusato
1,
Amedeo De Nicolò
1,
Renzo Lucchini
2,
Franco Keller
2 and
Marco Cantù
2
1
Laboratory of Clinical Pharmacology and Pharmacogenetics, Amedeo di Savoia Hospital, Department of Medical Sciences, University of Turin, 10126 Turin, Italy
2
Department of Laboratory Medicine EOLAB, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland, [email protected] (R.L.)
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(5), 1359; https://doi.org/10.3390/nu12051359
Received: 20 April 2020 / Revised: 6 May 2020 / Accepted: 7 May 2020 / Published: 9 May 2020
(This article belongs to the Section Micronutrients and Human Health)
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Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), with a clinical outcome ranging from mild to severe, including death. To date, it is unclear why some patients develop severe symptoms. Many authors have suggested the involvement of vitamin D in reducing the risk of infections; thus, we retrospectively investigated the 25-hydroxyvitamin D (25(OH)D) concentrations in plasma obtained from a cohort of patients from Switzerland. In this cohort, significantly lower 25(OH)D levels (p = 0.004) were found in PCR-positive for SARS-CoV-2 (median value 11.1 ng/mL) patients compared with negative patients (24.6 ng/mL); this was also confirmed by stratifying patients according to age >70 years. On the basis of this preliminary observation, vitamin D supplementation might be a useful measure to reduce the risk of infection. Randomized controlled trials and large population studies should be conducted to evaluate these recommendations and to confirm our preliminary observation. View Full-Text
Keywords: vitamin D; SARS-CoV-2; concentrations; COVID-19; coronavirus; deficiency vitamin D; SARS-CoV-2; concentrations; COVID-19; coronavirus; deficiency
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MDPI and ACS Style

D’Avolio, A.; Avataneo, V.; Manca, A.; Cusato, J.; De Nicolò, A.; Lucchini, R.; Keller, F.; Cantù, M. 25-Hydroxyvitamin D Concentrations Are Lower in Patients with Positive PCR for SARS-CoV-2. Nutrients 2020, 12, 1359. https://doi.org/10.3390/nu12051359

AMA Style

D’Avolio A, Avataneo V, Manca A, Cusato J, De Nicolò A, Lucchini R, Keller F, Cantù M. 25-Hydroxyvitamin D Concentrations Are Lower in Patients with Positive PCR for SARS-CoV-2. Nutrients. 2020; 12(5):1359. https://doi.org/10.3390/nu12051359

Chicago/Turabian Style

D’Avolio, Antonio, Valeria Avataneo, Alessandra Manca, Jessica Cusato, Amedeo De Nicolò, Renzo Lucchini, Franco Keller, and Marco Cantù. 2020. "25-Hydroxyvitamin D Concentrations Are Lower in Patients with Positive PCR for SARS-CoV-2" Nutrients 12, no. 5: 1359. https://doi.org/10.3390/nu12051359

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