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Open AccessArticle

Blueberry Prevents the Bladder Dysfunction in Bladder Outlet Obstruction Rats by Attenuating Oxidative Stress and Suppressing Bladder Remodeling

Department of Microbiology, School of Medicine, Fukushima Medical University, Fukushima 960-1295, Japan
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Author to whom correspondence should be addressed.
Nutrients 2020, 12(5), 1285; https://doi.org/10.3390/nu12051285
Received: 6 April 2020 / Revised: 30 April 2020 / Accepted: 30 April 2020 / Published: 1 May 2020
(This article belongs to the Section Phytochemicals and Human Health)
Various berries demonstrate antioxidant activity, and this effect is expected to prevent chronic diseases. We examined whether a diet containing blueberry powder could prevent the development of bladder dysfunction secondary to bladder outlet obstruction (BOO). Eighteen 8-week-old male Sprague-Dawley rats were randomly divided into three groups: Sham (sham operated + normal diet), N-BOO (BOO operated + normal diet) and B-BOO (BOO operated + blueberry diet). Four weeks after BOO surgery, the N-BOO group developed bladder dysfunction with detrusor overactivity. The B-BOO group showed significantly improved micturition volume and micturition interval. The urinary levels of 8-hydroxy-2′-deoxyguanosine (8-OHdG) and malondialdehyde (MDA) were measured as oxidative stress markers. In the N-BOO group, 8-OHdG increased 1.6-fold and MDA increased 1.3-fold at 4 weeks after surgery, whereas the increase in 8-OHdG was significantly reduced by 1.1-fold, despite a similar increase in MDA, in the B-BOO group. Bladder remodeling was confirmed due to bladder hypertrophy, fibrosis and increased connexin43 expression in the N-BOO group, but these histological changes were reduced in the B-BOO group. The intake of blueberries prevented the development of bladder dysfunction secondary to BOO. This effect seems to be related to antioxidation and the inhibition of bladder remodeling. View Full-Text
Keywords: blueberry; Overactive Bladder Symptoms; Bladder Outlet Obstruction; rat model; functional food blueberry; Overactive Bladder Symptoms; Bladder Outlet Obstruction; rat model; functional food
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MDPI and ACS Style

Miyazaki, N.; Katsura, R.; Hamada, K.; Suzutani, T. Blueberry Prevents the Bladder Dysfunction in Bladder Outlet Obstruction Rats by Attenuating Oxidative Stress and Suppressing Bladder Remodeling. Nutrients 2020, 12, 1285. https://doi.org/10.3390/nu12051285

AMA Style

Miyazaki N, Katsura R, Hamada K, Suzutani T. Blueberry Prevents the Bladder Dysfunction in Bladder Outlet Obstruction Rats by Attenuating Oxidative Stress and Suppressing Bladder Remodeling. Nutrients. 2020; 12(5):1285. https://doi.org/10.3390/nu12051285

Chicago/Turabian Style

Miyazaki, Nozomu; Katsura, Ryota; Hamada, Koki; Suzutani, Tatsuo. 2020. "Blueberry Prevents the Bladder Dysfunction in Bladder Outlet Obstruction Rats by Attenuating Oxidative Stress and Suppressing Bladder Remodeling" Nutrients 12, no. 5: 1285. https://doi.org/10.3390/nu12051285

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