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Open AccessArticle

Pyropia yezoensis Extract Suppresses IFN-Gamma- and TNF-Alpha-Induced Proinflammatory Chemokine Production in HaCaT Cells via the Down-Regulation of NF-κB

1
Research Institute of Basic Sciences, Incheon National University, Incheon 22012, Korea
2
Department of Cosmetic Science and Management, Graduate school, Incheon National University, Incheon 22012, Korea
3
Department of Marine Sciences, Incheon National University, Incheon 22012, Korea
4
Department of Genetic Engineering, College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon City, Gyunggi Do 164-19, Korea
*
Authors to whom correspondence should be addressed.
Nutrients 2020, 12(5), 1238; https://doi.org/10.3390/nu12051238
Received: 30 March 2020 / Revised: 22 April 2020 / Accepted: 25 April 2020 / Published: 27 April 2020
(This article belongs to the Special Issue Carotenoids in Human Nutrition)
Pyropia yezoensis, a red alga, is popular and harvested a lot in East Asia and is famous for its medicinal properties attributable to its bioactive compounds including amino acids (porphyra-334 and shinorine, etc.), polysaccharides, phytosterols, and pigments, but its anti-inflammatory effect and mechanism of anti-atopic dermatitis (AD) have not been elucidated. In this study, we investigate the anti-AD effect of P. yezoensis extract (PYE) on mRNA and protein levels of the pro-inflammatory chemokines, thymus, and activation-regulated chemokine (TARC/CCL17) and macrophage-derived chemokine (MDC/CCL22), in human HaCaT keratinocyte cells treated to interferon (IFN)-γ or tumor necrosis factor (TNF)-α (10 ng/mL each). The effect of the PYE on extracellular signal-regulated kinase (ERK) and other mitogen-activated protein kinases (MAPKs) was related to its suppression of TARC and MDC production by blocking NF-κB activation in HaCaT cells. Furthermore, astaxanthin and xanthophyll from P. yezoensis were identified as anti-AD candidate compounds. These results suggest that the PYE may improve AD and contained two carotenoids by regulating pro-inflammatory chemokines. View Full-Text
Keywords: Pyropia yezoensis; AD; TARC; MDC; astaxanthin; xanthophyll; mitogen-activated protein kinases; NF-κB Pyropia yezoensis; AD; TARC; MDC; astaxanthin; xanthophyll; mitogen-activated protein kinases; NF-κB
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Ha, Y.; Lee, W.-H.; Jeong, J.; Park, M.; Ko, J.-Y.; Kwon, O.W.; Lee, J.; Kim, Y.-J. Pyropia yezoensis Extract Suppresses IFN-Gamma- and TNF-Alpha-Induced Proinflammatory Chemokine Production in HaCaT Cells via the Down-Regulation of NF-κB. Nutrients 2020, 12, 1238.

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