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Association between Polyphenol Intake and Breast Cancer Risk by Menopausal and Hormone Receptor Status

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Group of Investigation in Interactions Gene-Environment and Health (GIIGAS)/Institute of Biomedicine (IBIOMED), Universidad de León, 24071 León, Spain
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Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet del Llobregat, 08908 Barcelona, Spain
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School of Medicine, University of Alcalá, 28871 Alcalá de Henares, Madrid, Spain
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Consortium for Biomedical Research in Epidemiology &
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Public Health Division of Gipuzkoa, BioDonostia Research Institute, 20014 San Sebastian, Spain
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Public Health Institute of Navarra, IdiSNA, 31003 Pamplona, Spain
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Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L’Hospitalet del Llobregat, 08908 Barcelona, Spain
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ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat, 08908 Barcelona, Spain
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Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain
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Oncology Institute, University of Oviedo, 33003 Oviedo, Spain
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Cancer and Public Health Area, FISABIO—Public Health, 46035 Valencia, Spain
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Centro de Investigación en Salud y Medio Ambiente (CYSMA), Universidad de Huelva, Campus Universitario de El Carmen, 21071 Huelva, Spain
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Catalan Institute of Oncology, Epidemiology Unit and Girona Cancer Registry, Oncology Coordination Plan, Department of Health, Autonomous Government of Catalonia, Catalan Institute of Oncology, 17007 Girona, Spain
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Descriptive Epidemiology, Genetics and Cancer Prevention Group, Biomedical Research Institute (IDIBGI), 17090 Girona, Spain
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Research Group on Statistics, Econometrics and Health (GRECS), University of Girona, 17004 Girona, Spain
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National Center for Epidemiology, Carlos III Institute of Health, 20014 San Sebastián, Spain
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Department of Oncology, Complejo Asistencial Universitario de León, 24071 León, Spain
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Biodonostia Health Research Institute, 20013 San Sebastian, Spain
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ISGlobal, Barcelona, 08036 Barcelona, Spain
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IMIM (Hospital del Mar Medical Research Institute), 08003 Barcelona, Spain
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Universitat Pompeu Fabra (UPF), Campus del Mar, 08003 Barcelona, Spain
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Universidad de Cantabria—IDIVAL, 39011 Santander, Spain
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Epidemiology Section, Public Health Division, Department of Health of Madrid, 28035 Madrid, Spain
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(4), 994; https://doi.org/10.3390/nu12040994
Received: 2 March 2020 / Revised: 27 March 2020 / Accepted: 2 April 2020 / Published: 3 April 2020
(This article belongs to the Special Issue Unhealthy Food Consumption and Cancer Risk)
There is limited evidence of phenolic compounds acting as protective agents on several cancer types, including breast cancer (BC). Nevertheless, some polyphenol classes have not been investigated and there is a lack of studies assessing the effect on menopausal status and hormone receptor status as influenced by these compounds. The objective of this study is to evaluate the association between the intake of all polyphenol classes in relation to the BC risk by menopausal and hormone receptor status. We used data from a population-based multi-case-control study (MCC-Spain) including 1472 BC cases and 1577 controls from 12 different regions of Spain. The odds ratios (ORs) with 95% CI were calculated using logistic regression of mixed effects by quartiles and log2 of polyphenol intakes (adjusted for the residual method) of overall BC, menopausal and receptor status. No associations were found between total intake of polyphenols and BC risk. However, inverse associations were found between stilbenes and all BC risk (ORQ4 vs. Q1: 0.70, 95%CI: 0.56–0.89, Ptrend = 0.001), the consumption of hydroxybenzaldehydes (ORQ4 vs. Q1: 0.75, 95%CI: 0.59–0.93, Ptrend = 0.012) and hydroxycoumarins (ORQ4 vs. Q1: 0.73, 95%CI: 0.57–0.93; Ptrend = 0.005) were also inversely associated. The intake of stilbenes, hydroxybenzaldehydes and hydroxycoumarins can contribute to BC reduction risk on all menopausal and receptor statuses. View Full-Text
Keywords: flavonoids; polyphenols; classes; intake; breast cancer; case-control flavonoids; polyphenols; classes; intake; breast cancer; case-control
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MDPI and ACS Style

Vitelli-Storelli, F.; Zamora-Ros, R.; Molina, A.J.; Fernández-Villa, T.; Castelló, A.; Barrio, J.P.; Amiano, P.; Ardanaz, E.; Obón-Santacana, M.; Gómez-Acebo, I.; Fernández-Tardón, G.; Molina-Barceló, A.; Alguacil, J.; Marcos-Gragera, R.; Ruiz-Moreno, E.; Pedraza, M.; Gil, L.; Guevara, M.; Castaño-Vinyals, G.; Dierssen-Sotos, T.; Kogevinas, M.; Aragonés, N.; Martín, V. Association between Polyphenol Intake and Breast Cancer Risk by Menopausal and Hormone Receptor Status. Nutrients 2020, 12, 994. https://doi.org/10.3390/nu12040994

AMA Style

Vitelli-Storelli F, Zamora-Ros R, Molina AJ, Fernández-Villa T, Castelló A, Barrio JP, Amiano P, Ardanaz E, Obón-Santacana M, Gómez-Acebo I, Fernández-Tardón G, Molina-Barceló A, Alguacil J, Marcos-Gragera R, Ruiz-Moreno E, Pedraza M, Gil L, Guevara M, Castaño-Vinyals G, Dierssen-Sotos T, Kogevinas M, Aragonés N, Martín V. Association between Polyphenol Intake and Breast Cancer Risk by Menopausal and Hormone Receptor Status. Nutrients. 2020; 12(4):994. https://doi.org/10.3390/nu12040994

Chicago/Turabian Style

Vitelli-Storelli, Facundo, Raul Zamora-Ros, Antonio J. Molina, Tania Fernández-Villa, Adela Castelló, Juan P. Barrio, Pilar Amiano, Eva Ardanaz, Mireia Obón-Santacana, Inés Gómez-Acebo, Guillermo Fernández-Tardón, Ana Molina-Barceló, Juan Alguacil, Rafael Marcos-Gragera, Emma Ruiz-Moreno, Manuela Pedraza, Leire Gil, Marcela Guevara, Gemma Castaño-Vinyals, Trinidad Dierssen-Sotos, Manolis Kogevinas, Nuria Aragonés, and Vicente Martín. 2020. "Association between Polyphenol Intake and Breast Cancer Risk by Menopausal and Hormone Receptor Status" Nutrients 12, no. 4: 994. https://doi.org/10.3390/nu12040994

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