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Open AccessArticle

Glutamine Supplementation Prevents Chronic Stress-Induced Mild Cognitive Impairment

Department of Anatomy and Convergence Medical Sciences, Bio Anti-aging Medical Research Center, Institute of Health Sciences, Gyeongsang National University Medical School, Jinju 52727, Korea
Authors to whom correspondence should be addressed.
Nutrients 2020, 12(4), 910;
Received: 27 February 2020 / Revised: 20 March 2020 / Accepted: 25 March 2020 / Published: 26 March 2020
(This article belongs to the Section Nutrition and Metabolism)
We recently reported that glutamine (Gln) supplementation protected glutamatergic neurotransmission from the harmful effects of chronic stress. Altered glutamatergic neurotransmission is one of the main causes of cognitive disorders. However, the cognitive enhancer function of Gln has not been clearly demonstrated thus far. Here, we evaluated whether and how Gln supplementation actually affects chronic stress-induced cognitive impairment. Using a chronic immobilization stress (CIS) mouse model, we confirmed that chronic stress induced mild cognitive impairment (MCI) and neuronal damage in the hippocampus. In contrast, Gln-supplemented mice did not show evidence of MCI. To investigate possible underlying mechanisms, we confirmed that CIS increased plasma corticosterone levels as well as brain and plasma levels of reactive oxygen/nitrogen species. CIS also increased levels of inducible nitric oxide synthase and NADPH oxidase subunits (p47phox and p67phox) in both the prefrontal cortex and CA1 region of the hippocampus. CIS decreased the number of synaptic puncta in the prefrontal cortex and hippocampus, but these effects were inhibited by Gln supplementation. Taken together, the present results suggest that Gln is an effective agent against chronic stress-induced MCI. View Full-Text
Keywords: chronic stress; mild cognitive impairment; glutamine; oxidative stress chronic stress; mild cognitive impairment; glutamine; oxidative stress
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MDPI and ACS Style

Baek, J.H.; Jung, S.; Son, H.; Kang, J.S.; Kim, H.J. Glutamine Supplementation Prevents Chronic Stress-Induced Mild Cognitive Impairment. Nutrients 2020, 12, 910.

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