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Open AccessArticle

Schisandra Extract and Ascorbic Acid Synergistically Enhance Cognition in Mice through Modulation of Mitochondrial Respiration

1
Department of Biochemistry, Chungnam National University School of Medicine, Daejeon 35015, Korea
2
Department of Medical Science, Chungnam National University School of Medicine, Daejeon 35015, Korea
3
Infection Control Convergence Research Center, Chungnam National University School of Medicine, Daejeon 35015, Korea
4
Department of Neurology, Chungnam National University Hospital, Daejeon 35015, Korea
5
Department of Anesthesiology and Pain Medicine, Chungnam National University Hospital, Daejeon 35015, Korea
6
Department of Anesthesiology and Pain Medicine, Chungnam National University School of Medicine, Daejeon 35015, Korea
7
Natural Product Research Team, Biocenter, Gyeonggido Business and Science Accelerator, Suwon 16229, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2020, 12(4), 897; https://doi.org/10.3390/nu12040897
Received: 24 February 2020 / Revised: 18 March 2020 / Accepted: 23 March 2020 / Published: 25 March 2020
(This article belongs to the Special Issue Nutrients and Brain across the Lifespan)
Cognitive decline is observed in aging and neurodegenerative diseases, including Alzheimer’s disease (AD) and dementia. Intracellular energy produced via mitochondrial respiration is used in the regulation of synaptic plasticity and structure, including dendritic spine length and density, as well as for the release of neurotrophic factors involved in learning and memory. To date, a few synthetic agents for improving mitochondrial function have been developed for overcoming cognitive impairment. However, no natural compounds that modulate synaptic plasticity by directly targeting mitochondria have been developed. Here, we demonstrate that a mixture of Schisandra chinensis extract (SCE) and ascorbic acid (AA) improved cognitive function and induced synaptic plasticity-regulating proteins by enhancing mitochondrial respiration. Treatment of embryonic mouse hippocampal mHippoE-14 cells with a 4:1 mixture of SCE and AA increased basal oxygen consumption rate. We found that mice injected with the SCE-AA mixture showed enhanced learning and memory and recognition ability. We further observed that injection of the SCE-AA mixture in mice significantly increased expression of postsynaptic density protein 95 (PSD95), an increase that was correlated with enhanced brain-derived neurotrophic factor (BDNF) expression. These results demonstrate that a mixture of SCE and AA improves mitochondrial function and memory, suggesting that this natural compound mixture could be used to alleviate AD and aging-associated memory decline. View Full-Text
Keywords: schisandra extract; ascorbic acid; mitochondria; synaptic plasticity; hippocampus schisandra extract; ascorbic acid; mitochondria; synaptic plasticity; hippocampus
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Jang, Y.; Lee, J.H.; Lee, M.J.; Kim, S.J.; Ju, X.; Cui, J.; Zhu, J.; Lee, Y.L.; Namgung, E.; Sung, H.W.J.; Lee, H.W.; Ryu, M.J.; Oh, E.; Chung, W.; Kweon, G.R.; Choi, C.W.; Heo, J.Y. Schisandra Extract and Ascorbic Acid Synergistically Enhance Cognition in Mice through Modulation of Mitochondrial Respiration. Nutrients 2020, 12, 897.

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