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Article

Efficacy of Lactobacillus paracasei HA-196 and Bifidobacterium longum R0175 in Alleviating Symptoms of Irritable Bowel Syndrome (IBS): A Randomized, Placebo-Controlled Study

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KGK Science Inc., London, ON N6A 5R8, Canada
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Lallemand Health Solutions, Montreal, QC H4P 2R2, Canada
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(4), 1159; https://doi.org/10.3390/nu12041159
Received: 5 February 2020 / Revised: 19 March 2020 / Accepted: 16 April 2020 / Published: 21 April 2020
(This article belongs to the Section Prebiotics and Probiotics)
Specific probiotic strains can alleviate the gastrointestinal (GI) symptoms and psychiatric comorbidities of irritable bowel syndrome (IBS). In this randomized, double-blind, placebo-controlled study, the efficacy of Lactobacillus paracasei HA-196 (L. paracasei) and Bifidobacterium longum R0175 (B. longum) in reducing the GI and psychological symptoms of IBS was evaluated in 251 adults with either constipation (IBS-C), diarrhea (IBS-D), or mixed-pattern (IBS-M). Following a 2-week run-in period, participants were randomized to one of three interventions: L. paracasei (n = 84), B. longum (n = 83) or placebo (n = 81). IBS symptoms, stool frequency and consistency and quality of life were assessed by questionnaires. The differences from baseline in the severity of IBS symptoms at 4 and 8 weeks were similar between groups. Participants in this study were classified, after randomization, into subtypes according to Rome III. Within the L. paracasei group, complete spontaneous and spontaneous bowel movement frequency increased in participants with IBS-C (n = 10) after 8 weeks of supplementation (both p < 0.05) and decreased in participants with IBS-D (n = 10, p = 0.013). Both L. paracasei and B. longum supplementation improved the quality of life in emotional well-being and social functioning compared with baseline (all p < 0.05). In conclusion, L. paracasei and B. longum may reduce GI symptom severity and improve the psychological well-being of individuals with certain IBS subtypes. View Full-Text
Keywords: probiotics; Bifidobacterium longum; Lactobacillus paracasei; Irritable Bowel Syndrome; IBS probiotics; Bifidobacterium longum; Lactobacillus paracasei; Irritable Bowel Syndrome; IBS
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MDPI and ACS Style

Lewis, E.D.; Antony, J.M.; Crowley, D.C.; Piano, A.; Bhardwaj, R.; Tompkins, T.A.; Evans, M. Efficacy of Lactobacillus paracasei HA-196 and Bifidobacterium longum R0175 in Alleviating Symptoms of Irritable Bowel Syndrome (IBS): A Randomized, Placebo-Controlled Study. Nutrients 2020, 12, 1159. https://doi.org/10.3390/nu12041159

AMA Style

Lewis ED, Antony JM, Crowley DC, Piano A, Bhardwaj R, Tompkins TA, Evans M. Efficacy of Lactobacillus paracasei HA-196 and Bifidobacterium longum R0175 in Alleviating Symptoms of Irritable Bowel Syndrome (IBS): A Randomized, Placebo-Controlled Study. Nutrients. 2020; 12(4):1159. https://doi.org/10.3390/nu12041159

Chicago/Turabian Style

Lewis, Erin D., Joseph M. Antony, David C. Crowley, Amanda Piano, Renu Bhardwaj, Thomas A. Tompkins, and Malkanthi Evans. 2020. "Efficacy of Lactobacillus paracasei HA-196 and Bifidobacterium longum R0175 in Alleviating Symptoms of Irritable Bowel Syndrome (IBS): A Randomized, Placebo-Controlled Study" Nutrients 12, no. 4: 1159. https://doi.org/10.3390/nu12041159

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