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Open AccessReview

Single Nucleotide Polymorphisms in 25-Hydroxyvitamin D3 1-Alpha-Hydroxylase (CYP27B1) Gene: The Risk of Malignant Tumors and Other Chronic Diseases

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Faculty of Biology and Biotechnology, University of Warmia and Mazury, 10-719 Olsztyn, Poland
2
Faculty of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, 10-082 Olsztyn, Poland
3
Department of General Surgery, Faculty of Medical Sciences, Collegium Medicum, University of Warmia and Mazury, 10-082 Olsztyn, Poland
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Independent Public Healthcare Center of Ministry of Internal Affairs and Administration with the Warmia and Mazury, Center of Oncology in Olsztyn, 10-228 Olsztyn, Poland
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Cell Biology and Immunology Group Wageningen University and Research, 6700 AH Wageningen, The Netherlands
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Clinical Department of Trauma-Orthopedic Surgery and Spine Surgery of the Provincial Specialist Hospital in Olsztyn, 10-561 Olsztyn, Poland
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Clinical Department of Orthopedics, Traumatology and Spine Surgery, Collegium Medicum, University of Warmia and Mazury, 10-719 Olsztyn, Poland
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(3), 801; https://doi.org/10.3390/nu12030801
Received: 29 February 2020 / Revised: 13 March 2020 / Accepted: 16 March 2020 / Published: 18 March 2020
(This article belongs to the Special Issue The Role of Vitamin D in Chronic Diseases)
Vitamin D is widely known for its roles in the promotion of apoptosis and differentiation, with simultaneous inhibition of proliferation, inflammation, angiogenesis, invasion, and metastasis. Modern literature lacks complete information on polymorphisms in CYP27B1, the only enzyme capable of vitamin D activation. This review presents gathered data that relate to genetic variants in CYP27B1 gene in correlation to multiple diseases, mostly concerning colorectal, prostate, breast, lung, and pancreatic cancers, as well as on other pathologies, such as non-Hodgkin’s lymphoma, oral lichen planus, or multiple sclerosis. View Full-Text
Keywords: vitamin D; single nucleotide polymorphism; CYP27B1; chronic diseases; colorectal cancer; breast cancer; prostate cancer; multiple sclerosis vitamin D; single nucleotide polymorphism; CYP27B1; chronic diseases; colorectal cancer; breast cancer; prostate cancer; multiple sclerosis
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MDPI and ACS Style

Latacz, M.; Snarska, J.; Kostyra, E.; Fiedorowicz, E.; Savelkoul, H.F.J.; Grzybowski, R.; Cieślińska, A. Single Nucleotide Polymorphisms in 25-Hydroxyvitamin D3 1-Alpha-Hydroxylase (CYP27B1) Gene: The Risk of Malignant Tumors and Other Chronic Diseases. Nutrients 2020, 12, 801.

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