Next Article in Journal
Intradialytic Nutrition and Hemodialysis Prescriptions: A Personalized Stepwise Approach
Next Article in Special Issue
Second Version of a Mini-Survey to Evaluate Food Intake Quality (Mini-ECCA v.2): Reproducibility and Ability to Identify Dietary Patterns in University Students
Previous Article in Journal
Vitamin D Supplementation in Multiple Sclerosis: A Critical Analysis of Potentials and Threats
Previous Article in Special Issue
Associations of Breast Milk Microbiota, Immune Factors, and Fatty Acids in the Rat Mother–Offspring Pair
Open AccessArticle

Comparative Bioavailability of Different Coenzyme Q10 Formulations in Healthy Elderly Individuals

1
Nutrition Institute, Tržaška cesta 40, SI-1000 Ljubljana, Slovenia
2
Biotechnical Faculty, University of Ljubljana, Jamnikarjeva 101, 1000 Ljubljana, Slovenia
3
Department of Physiology, Anatomy and Cell Biology, Pablo de Olavide University, 41013 Seville, Spain
4
Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia
5
VIST—Higher School of Applied Sciences, Gerbičeva cesta 51A, SI-1000 Ljubljana, Slovenia
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(3), 784; https://doi.org/10.3390/nu12030784
Received: 7 February 2020 / Revised: 5 March 2020 / Accepted: 11 March 2020 / Published: 16 March 2020
Coenzyme Q10 (CoQ10) plays a central role in mitochondrial oxidative phosphorylation. Several studies have shown the beneficial effects of dietary CoQ10 supplementation, particularly in relation to cardiovascular health. CoQ10 biosynthesis decreases in the elderly, and consequently, the beneficial effects of dietary supplementation in this population are of greater significance. However, most pharmacokinetic studies have been conducted on younger populations. The aim of this study was to investigate the single-dose bioavailability of different formulations of CoQ10 in a healthy geriatric population. A randomized, three-period, crossover bioavailability study was conducted on 21 healthy older adults (aged 65–74). The treatment was a single dose with a one-week washout period. Three different formulations containing the equivalent of 100 mg of CoQ10 were used: Q10Vital® water-soluble CoQ10 syrup (the investigational product—IP); ubiquinol capsules (the comparative product—CP); and ubiquinone capsules (the standard product—SP). Ubiquinone/ubiquinol was followed in the plasma for 48 h. An analysis of the ratio of the area under the baseline-corrected concentration curve (ΔAUC48) for total CoQ10 and a comparison to SP yielded the following: The bioavailability of CoQ10 in the IP was 2.4-fold higher (95% CI: 1.3–4.5; p = 0.002), while the bioavailability of ubiquinol (CP) was not significantly increased (1.7-fold; 95% CI: 0.9–3.1, p = 0.129). No differences in the redox status of the absorbed coenzyme Q10 were observed between formulations, showing that CoQ10 appeared in the blood mostly as ubiquinol, even if consumed as ubiquinone. View Full-Text
Keywords: coenzyme Q10; CoQ10; Q10Vital®; ubiquinone; ubiquinol; bioavailability; water-soluble formulations; the elderly coenzyme Q10; CoQ10; Q10Vital®; ubiquinone; ubiquinol; bioavailability; water-soluble formulations; the elderly
Show Figures

Graphical abstract

MDPI and ACS Style

Pravst, I.; Rodríguez Aguilera, J.C.; Cortes Rodriguez, A.B.; Jazbar, J.; Locatelli, I.; Hristov, H.; Žmitek, K. Comparative Bioavailability of Different Coenzyme Q10 Formulations in Healthy Elderly Individuals. Nutrients 2020, 12, 784.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop