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Inflammation (IL-1β) Modifies the Effect of Vitamin D and Omega-3 Long Chain Polyunsaturated Fatty Acids on Core Symptoms of Autism Spectrum Disorder—An Exploratory Pilot Study

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School of Sport, Exercise and Nutrition, College of Health, Massey University, Auckland 0745, New Zealand
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School of Health Sciences, College of Health, Massey University, Palmerston North 4442, New Zealand
3
Riddet Institute, Massey University, Palmerston North 4442, New Zealand
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Commonwealth Scientific and Industrial Research Organisation (CSIRO), Adelaide, SA 5000, Australia
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Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
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School of Medicine, Lipid Research Centre, Molecular Horizons, University of Wollongong, Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia
7
Department of Paediatrics, Child and Youth Health, University of Auckland, Auckland 1023, New Zealand
*
Author to whom correspondence should be addressed.
Presented at The Nutrition Society of New Zealand Annual Conference in Napier, New Zealand, 28th to 29th November 2019.
Nutrition Society of New Zealand member.
Nutrients 2020, 12(3), 661; https://doi.org/10.3390/nu12030661
Received: 18 January 2020 / Revised: 26 February 2020 / Accepted: 27 February 2020 / Published: 28 February 2020
Background: The role of vitamin D and omega-3 long chain polyunsaturated fatty acids (omega-3 LCPUFA) in improving core symptoms of autism spectrum disorder (ASD) in children has been investigated by a few randomised controlled trials and the results are mixed and inconclusive. The response to treatment with these nutrients is heterogenous and may be influenced by inflammatory state. As an exploratory analysis, we investigated whether inflammatory state would modulate the effect of these nutrients on core symptoms of ASD. Methods: Seventy-three New Zealand children with ASD (2.5–8.0 years) completed a 12-month randomised, double-blind, placebo-controlled trial of vitamin D (VID, 2000 IU/day), omega-3 LCPUFA; (OM, 722 mg/day docosahexaenoic acid), or both (VIDOM). Non-fasting baseline plasma interleukin-1β (IL-1β) was available for 67 children (VID = 15, OM = 21, VIDOM = 15, placebo = 16). Children were categorised as having undetectable/normal IL-1β (<3.2 pg/ml, n = 15) or elevated IL-1β (≥3.2 pg/mL, n = 52). The Social Responsiveness Scale (SRS) questionnaire was used to assess core symptoms of ASD (baseline, 12-month). Mixed model repeated measure analyses (including all children or only children with elevated IL-1β) were used. Results: We found evidence for an interaction between baseline IL-1β and treatment response for SRS-total, SRS-social communicative functioning, SRS-awareness and SRS-communication (all Pinteraction < 0.10). When all children were included in the analysis, two outcome comparisons (treatments vs. placebo) showed greater improvements: VID, no effect (all P > 0.10); OM and VIDOM (P = 0.01) for SRS-awareness. When only children with elevated IL-1β were included, five outcomes showed greater improvements: OM (P = 0.01) for SRS-total; OM (P = 0.03) for SRS-social communicative functioning; VID (P = 0.01), OM (P = 0.003) and VIDOM (P = 0.01) for SRS-awareness. Conclusion: Inflammatory state may have modulated responses to vitamin D and omega-3 LCPUFA intervention in children with ASD, suggesting children with elevated inflammation may benefit more from daily vitamin D and omega-3 LCPUFA supplementation. View Full-Text
Keywords: autism; inflammation; interleukin 1; vitamin D; omega-3; intervention autism; inflammation; interleukin 1; vitamin D; omega-3; intervention
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Mazahery, H.; Conlon, C.A.; Beck, K.L.; Mugridge, O.; Kruger, M.C.; Stonehouse, W.; Camargo, C.A., Jr.; Meyer, B.J.; Tsang, B.; von Hurst, P.R. Inflammation (IL-1β) Modifies the Effect of Vitamin D and Omega-3 Long Chain Polyunsaturated Fatty Acids on Core Symptoms of Autism Spectrum Disorder—An Exploratory Pilot Study . Nutrients 2020, 12, 661.

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