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Article

Safety of Short-Term Supplementation with Methylliberine (Dynamine®) Alone and in Combination with TeaCrine® in Young Adults

1
Department of Exercise Science and Sport Management, Kennesaw State University, Kennesaw, GA 30144, USA
2
Kinesiology and Sport Management, Texas Tech University, Lubbock, TX 79409, USA
3
Southern Regional Physician Management Group, LLC, Riverdale, GA 30274, USA
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(3), 654; https://doi.org/10.3390/nu12030654
Received: 6 February 2020 / Revised: 22 February 2020 / Accepted: 25 February 2020 / Published: 28 February 2020
Methylliberine (Dynamine®; DYM) and theacrine (Teacrine®; TCR) are purine alkaloids purported to have similar neuro-energetic effects as caffeine. There are no published human safety data on DYM, and research on TCR is limited. The purpose of this study was to examine the effect of four weeks of DYM supplementation with and without TCR on cardiovascular function and blood biomarkers. One-hundred twenty-five men and women (mean age 23.0 yrs, height 169.7 cm, body mass 72.1 kg; n = 25/group) were randomly assigned to one of five groups: low-dose DYM (100 mg), high-dose DYM (150 mg), low-dose DYM with TCR (100 mg + 50 mg), high-dose DYM with TCR (150 mg + 25 mg), and placebo. Regardless of group and sex, significant main effects for time were noted for heart rate, systolic blood pressure, and QTc (p < 0.001), high-density lipoproteins (p = 0.002), mean corpuscular hemoglobin (p = 0.018), basophils (p = 0.006), absolute eosinophils (p = 0.010), creatinine (p = 0.004), estimated glomerular filtration rate (p = 0.037), chloride (p = 0.030), carbon dioxide (p = 0.023), bilirubin (p = 0.027), and alanine aminotransferase (p = 0.043), among others. While small changes were found in some cardiovascular and blood biomarkers, no clinically significant changes occurred. This suggests that DYM alone or in combination with TCR consumed at the dosages used in this study does not appear to negatively affect markers of health over four weeks of continuous use. View Full-Text
Keywords: TeaCrine®; Dynamine®; theacrine; methylliberine; purine alkaloid TeaCrine®; Dynamine®; theacrine; methylliberine; purine alkaloid
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MDPI and ACS Style

VanDusseldorp, T.A.; Stratton, M.T.; Bailly, A.R.; Holmes, A.J.; Alesi, M.G.; Feito, Y.; Mangine, G.T.; Hester, G.M.; Esmat, T.A.; Barcala, M.; Tuggle, K.R.; Snyder, M.; Modjeski, A.S. Safety of Short-Term Supplementation with Methylliberine (Dynamine®) Alone and in Combination with TeaCrine® in Young Adults. Nutrients 2020, 12, 654. https://doi.org/10.3390/nu12030654

AMA Style

VanDusseldorp TA, Stratton MT, Bailly AR, Holmes AJ, Alesi MG, Feito Y, Mangine GT, Hester GM, Esmat TA, Barcala M, Tuggle KR, Snyder M, Modjeski AS. Safety of Short-Term Supplementation with Methylliberine (Dynamine®) Alone and in Combination with TeaCrine® in Young Adults. Nutrients. 2020; 12(3):654. https://doi.org/10.3390/nu12030654

Chicago/Turabian Style

VanDusseldorp, Trisha A., Matthew T. Stratton, Alyssa R. Bailly, Alyssa J. Holmes, Michaela G. Alesi, Yuri Feito, Gerald T. Mangine, Garrett M. Hester, Tiffany A. Esmat, Megan Barcala, Karleena R. Tuggle, Michael Snyder, and Andrew S. Modjeski 2020. "Safety of Short-Term Supplementation with Methylliberine (Dynamine®) Alone and in Combination with TeaCrine® in Young Adults" Nutrients 12, no. 3: 654. https://doi.org/10.3390/nu12030654

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