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Article

Evidence for Dietary Agmatine Sulfate Effectiveness in Neuropathies Associated with Painful Small Fiber Neuropathy. A Pilot Open-Label Consecutive Case Series Study

1
JFK Neuroscience Institute, JFK Medical Center, 65 James Street, Edison, NJ 08820, USA
2
Research, Gilad&Gilad LLC, Henderson, NV 89015, USA
*
Authors to whom correspondence should be addressed.
Nutrients 2020, 12(2), 576; https://doi.org/10.3390/nu12020576
Received: 30 January 2020 / Revised: 15 February 2020 / Accepted: 18 February 2020 / Published: 23 February 2020
(This article belongs to the Special Issue Diet and Nutrition in Neuropathic Pain and Headache)
Peripheral neuropathies associated with painful small fiber neuropathy (SFN) are complex conditions, resistant to treatment with conventional medications. Previous clinical studies strongly support the use of dietary agmatine as a safe and effective treatment for neuropathic pain. Based on this evidence, we conducted an open-label consecutive case series study to evaluate the effectiveness of agmatine in neuropathies associated with painful SFN (Study Registry: ClinicalTrials.gov, System Identifier: NCT01524666). Participants diagnosed with painful SFN and autonomic dysfunctions were treated with 2.67 g/day agmatine sulfate (AgmaSet® capsules containing G-Agmatine® brand of agmatine sulfate) for a period of 2 months. Before the beginning (baseline) and at the end of the treatment period, participants answered the established 12-item neuropathic pain questionnaire specifically developed to distinguish symptoms associated with neuropathy and to quantify their severity. Secondary outcomes included other treatment options and a safety assessment. Twelve patients were recruited, and 11 patients—8 diagnosed with diabetic neuropathy, two with idiopathic neuropathy and one with inflammatory neuropathy—completed the study. All patients showed improvement in neuropathic pain to a varied extent. The average decrease in pain intensity was 26.0 rating points, corresponding to a 46.4% reduction in overall pain (p < 0.00001). The results suggest that dietary agmatine sulfate has a significant effect in reducing neuropathic pain intensity associated with painful SFN resistant to treatment with conventional neuropathic pain medications. Larger randomized placebo-controlled studies are expected to establish agmatine sulfate as a preferred treatment. View Full-Text
Keywords: agmatine; neuropathic pain; neuropathies; peripheral neuropathy; small fiber neuropathy agmatine; neuropathic pain; neuropathies; peripheral neuropathy; small fiber neuropathy
MDPI and ACS Style

Rosenberg, M.L.; Tohidi, V.; Sherwood, K.; Gayen, S.; Medel, R.; Gilad, G.M. Evidence for Dietary Agmatine Sulfate Effectiveness in Neuropathies Associated with Painful Small Fiber Neuropathy. A Pilot Open-Label Consecutive Case Series Study. Nutrients 2020, 12, 576. https://doi.org/10.3390/nu12020576

AMA Style

Rosenberg ML, Tohidi V, Sherwood K, Gayen S, Medel R, Gilad GM. Evidence for Dietary Agmatine Sulfate Effectiveness in Neuropathies Associated with Painful Small Fiber Neuropathy. A Pilot Open-Label Consecutive Case Series Study. Nutrients. 2020; 12(2):576. https://doi.org/10.3390/nu12020576

Chicago/Turabian Style

Rosenberg, Michael L., Vahid Tohidi, Karna Sherwood, Sujoy Gayen, Rosina Medel, and Gad M. Gilad. 2020. "Evidence for Dietary Agmatine Sulfate Effectiveness in Neuropathies Associated with Painful Small Fiber Neuropathy. A Pilot Open-Label Consecutive Case Series Study" Nutrients 12, no. 2: 576. https://doi.org/10.3390/nu12020576

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