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Open AccessArticle

Beneficial Effect of Ubiquinol on Hematological and Inflammatory Signaling during Exercise

Institute of Nutrition and Food Technology “José Mataix”, University of Granada, Biomedical Research Centre, Health-Sciencies Technological Park, Avenida del Conocimiento s/n, Armilla, E-18071 Granada, Spain
Department of Physiology, University of Granada, E-18071 Granada, Spain
Departament of Physical Education, University of Granada, E-18071 Granada, Spain
Faculty of Health Sciences, University of Granada, E-18071 Granada, Spain
Author to whom correspondence should be addressed.
Nutrients 2020, 12(2), 424;
Received: 13 January 2020 / Revised: 29 January 2020 / Accepted: 4 February 2020 / Published: 6 February 2020
(This article belongs to the Special Issue Nutrition for Anemia)
Strenuous exercise (any activity that expends six metabolic equivalents per minute or more causing sensations of fatigue and exhaustion to occur, inducing deleterious effects, affecting negatively different cells), induces muscle damage and hematological changes associated with high production of pro-inflammatory mediators related to muscle damage and sports anemia. The objective of this study was to determine whether short-term oral ubiquinol supplementation can prevent accumulation of inflammatory mediators and hematological impairment associated to strenuous exercise. For this purpose, 100 healthy and well-trained firemen were classified in two groups: Ubiquinol (experimental group), and placebo group (control). The protocol was two identical strenuous exercise tests with rest period between tests of 24 h. Blood samples were collected before supplementation (basal value) (T1), after supplementation (T2), after first physical exercise test (T3), after 24 h of rest (T4), and after second physical exercise test (T5). Hematological parameters, pro- and anti-inflammatory cytokines and growth factors were measured. Red blood cells (RBC), hematocrit, hemoglobin, VEGF, NO, EGF, IL-1ra, and IL-10 increased in the ubiquinol group while IL-1, IL-8, and MCP-1 decreased. Ubiquinol supplementation during high intensity exercise could modulate inflammatory signaling, expression of pro-inflammatory, and increasing some anti-inflammatory cytokines. During exercise, RBC, hemoglobin, hematocrit, VEGF, and EGF increased in ubiquinol group, revealing a possible pro-angiogenic effect, improving oxygen supply and exerting a possible protective effect on other physiological alterations. View Full-Text
Keywords: high intensity exercise; ubiquinol; hematological parameters; inflammation; ergogenic effect high intensity exercise; ubiquinol; hematological parameters; inflammation; ergogenic effect
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Diaz-Castro, J.; Moreno-Fernandez, J.; Chirosa, I.; Chirosa, L.J.; Guisado, R.; Ochoa, J.J. Beneficial Effect of Ubiquinol on Hematological and Inflammatory Signaling during Exercise. Nutrients 2020, 12, 424.

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