Next Article in Journal
Identification and Comparison of Peptides from Chickpea Protein Hydrolysates Using Either Bromelain or Gastrointestinal Enzymes and Their Relationship with Markers of Type 2 Diabetes and Bitterness
Previous Article in Journal
Metabolic and Nutritional Issues Associated with Spinal Muscular Atrophy
Previous Article in Special Issue
Innovations in Infant Feeding: Future Challenges and Opportunities in Obesity and Cardiometabolic Disease
Article

Interaction Effect of the Mediterranean Diet and an Obesity Genetic Risk Score on Adiposity and Metabolic Syndrome in Adolescents: The HELENA Study

1
Growth, Exercise, NUtrition and Development (GENUD) Research Group, Faculty of Health Sciences, Instituto Agroalimentario de Aragón (IA2), Instituto de Investigación Sanitaria Aragón (IIS Aragón), Universidad de Zaragoza, 50009 Zaragoza, Spain
2
Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain
3
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029 Madrid, Spain
4
ImFine Research Group, Department of Health and Human Performance, Facultad de Ciencias de la Actividad Física y del Deporte-INEF, Universidad Politécnica de Madrid, 28040 Madrid, Spain
5
Institute of Nutritional and Food Sciences, Nutritional Physiology, University of Bonn, 53113 Bonn, Germany
6
EFFECTS 262 Department of Medical Physiology, School of Medicine, University of Granada, 18071 Granada, Spain
7
Department of Public Health and Primary Care, Faculty of Medicine and Health Sciences, Ghent University, 9000 Ghent, Belgium
8
Department of Pediatrics, Medical School, University of Pécs, 7623 Pécs, Hungary
9
Council for Agricultural Research and Economics-Research Center for Food and Nutrition, 00198 Rome, Italy
10
Department of Nutrition and Dietetics, School of Health Science & Education, Harokopio University, 176 71 Athens, Greece
11
Division of Gastroenterology and Hepatology, Department of Internal Med III, Austria and Austrian Academic Institute for Clinical Nutrition, 1090 Vienna, Austria
12
Faculty of Medicine, University of Crete, 715 00 Crete, Greece
13
CIC-1403-Inserm-CHU, Clinical Investigation Center, LIRIC UMR 995 Inserm, CHU Lille, Université de Lille, 59000 Lille, France
14
UMR1167, RID-AGE, Risk Factors and Molecular Determinants of Aging-Related Diseases, Centre Hosp, Institut Pasteur de Lille, Université de Lille, 59019 Lille, France
15
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85719, USA
16
PROmoting FITness and Health through Physical Activity Research Group (PROFITH), Department of Physical and Sports Education, School of Sports Science, Sport and Health University Research Institute (iMUDS), University of Granada, 18016 Granada, Spain
17
Escuela Politécnica de La Almunia, Universidad de Zaragoza, 50100 Zaragoza, Spain
18
Department of Health Sciences, Public University of Navarra, 31006 Pamplona, Spain
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(12), 3841; https://doi.org/10.3390/nu12123841
Received: 5 November 2020 / Revised: 11 December 2020 / Accepted: 14 December 2020 / Published: 16 December 2020
(This article belongs to the Special Issue Precision Nutrition)
Obesity and metabolic syndrome (MetS) are worldwide major health challenges. The Mediterranean diet (MD) is associated with a better cardiometabolic profile, but these beneficial effects may be influenced by genetic variations, modulating the predisposition to obesity or MetS. The aim was to assess whether interaction effects occur between an obesity genetic risk score (obesity-GRS) and the MD on adiposity and MetS in European adolescents. Multiple linear regression models were used to assess the interaction effects of an obesity-GRS and the MD on adiposity and MetS and its components. Interaction effects between the MD on adiposity and MetS were observed in both sex groups (p < 0.05). However, those interaction effects were only expressed in a certain number of adolescents, when a limited number of risk alleles were present. Regarding adiposity, a total of 51.1% males and 98.7% females had lower body mass index (BMI) as a result of higher MD adherence. Concerning MetS, only 9.9% of males with higher MD adherence had lower MetS scores. However, the same effect was observed in 95.2% of females. In conclusion, obesity-related genotypes could modulate the relationship between MD adherence and adiposity and MetS in European adolescents; the interaction effect was higher in females than in males. View Full-Text
Keywords: metabolic syndrome; Mediterranean diet; genetic risk score; HELENA; adolescents; sex metabolic syndrome; Mediterranean diet; genetic risk score; HELENA; adolescents; sex
Show Figures

Figure 1

MDPI and ACS Style

Seral-Cortes, M.; Sabroso-Lasa, S.; De Miguel-Etayo, P.; Gonzalez-Gross, M.; Gesteiro, E.; Molina-Hidalgo, C.; De Henauw, S.; Erhardt, É.; Censi, L.; Manios, Y.; Karaglani, E.; Widhalm, K.; Kafatos, A.; Beghin, L.; Meirhaeghe, A.; Salazar-Tortosa, D.; Ruiz, J.R.; Moreno, L.A.; Esteban, L.M.; Labayen, I. Interaction Effect of the Mediterranean Diet and an Obesity Genetic Risk Score on Adiposity and Metabolic Syndrome in Adolescents: The HELENA Study. Nutrients 2020, 12, 3841. https://doi.org/10.3390/nu12123841

AMA Style

Seral-Cortes M, Sabroso-Lasa S, De Miguel-Etayo P, Gonzalez-Gross M, Gesteiro E, Molina-Hidalgo C, De Henauw S, Erhardt É, Censi L, Manios Y, Karaglani E, Widhalm K, Kafatos A, Beghin L, Meirhaeghe A, Salazar-Tortosa D, Ruiz JR, Moreno LA, Esteban LM, Labayen I. Interaction Effect of the Mediterranean Diet and an Obesity Genetic Risk Score on Adiposity and Metabolic Syndrome in Adolescents: The HELENA Study. Nutrients. 2020; 12(12):3841. https://doi.org/10.3390/nu12123841

Chicago/Turabian Style

Seral-Cortes, Miguel, Sergio Sabroso-Lasa, Pilar De Miguel-Etayo, Marcela Gonzalez-Gross, Eva Gesteiro, Cristina Molina-Hidalgo, Stefaan De Henauw, Éva Erhardt, Laura Censi, Yannis Manios, Eva Karaglani, Kurt Widhalm, Anthony Kafatos, Laurent Beghin, Aline Meirhaeghe, Diego Salazar-Tortosa, Jonatan R. Ruiz, Luis A. Moreno, Luis M. Esteban, and Idoia Labayen. 2020. "Interaction Effect of the Mediterranean Diet and an Obesity Genetic Risk Score on Adiposity and Metabolic Syndrome in Adolescents: The HELENA Study" Nutrients 12, no. 12: 3841. https://doi.org/10.3390/nu12123841

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop