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Article

Low Levels of Omega-3 Long-Chain Polyunsaturated Fatty Acids Are Associated with Bone Metastasis Formation in Premenopausal Women with Breast Cancer: A Retrospective Study

1
Department of Gynecology, Centre Hospitalier Régional Universitaire de Tours, Hôpital Bretonneau, 2 Boulevard Tonnellé, 37044 Tours, France
2
Laboratoire N2C « Nutrition, Croissance et Cancer », Université de Tours, INSERM UMR1069, 10 Boulevard Tonnellé, 37032 Tours, France
3
Department of Pathology, Centre Hospitalier Régional Universitaire de Tours, Hôpital Bretonneau, 2 Boulevard Tonnellé, 37044 Tours, France
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(12), 3832; https://doi.org/10.3390/nu12123832
Received: 9 October 2020 / Revised: 23 November 2020 / Accepted: 12 December 2020 / Published: 15 December 2020
(This article belongs to the Special Issue Dietary Fat and Human Health Outcomes)
In the present study, we investigated various biochemical, clinical, and histological factors associated with bone metastases in a large cohort of pre- and postmenopausal women with breast cancer. Two hundred and sixty-one consecutive women with breast cancer were included in this study. Breast adipose tissue specimens were collected during surgery. After having established the fatty acid profile of breast adipose tissue by gas chromatography, we determined whether there were differences associated with the occurrence of bone metastases in these patients. Regarding the clinical and histological criteria, a majority of the patients with bone metastases (around 70%) had tumors with a luminal phenotype and 59% of them showed axillary lymph node involvement. Moreover, we found a negative association between the levels of n-3 long-chain polyunsaturated fatty acids (LC-PUFA) in breast adipose tissue and the development of bone metastases in premenopausal women. No significant association was observed in postmenopausal women. In addition to a luminal phenotype and axillary lymph node involvement, low levels of n-3 LC-PUFA in breast adipose tissue may constitute a risk factor that contributes to breast cancer bone metastases formation in premenopausal women. View Full-Text
Keywords: breast cancer; bone metastases; n-3 long-chain polyunsaturated fatty acids; adipose tissue breast cancer; bone metastases; n-3 long-chain polyunsaturated fatty acids; adipose tissue
MDPI and ACS Style

Goupille, C.; Frank, P.G.; Arbion, F.; Jourdan, M.-L.; Guimaraes, C.; Pinault, M.; Body, G.; Chevalier, S.; Bougnoux, P.; Ouldamer, L. Low Levels of Omega-3 Long-Chain Polyunsaturated Fatty Acids Are Associated with Bone Metastasis Formation in Premenopausal Women with Breast Cancer: A Retrospective Study. Nutrients 2020, 12, 3832. https://doi.org/10.3390/nu12123832

AMA Style

Goupille C, Frank PG, Arbion F, Jourdan M-L, Guimaraes C, Pinault M, Body G, Chevalier S, Bougnoux P, Ouldamer L. Low Levels of Omega-3 Long-Chain Polyunsaturated Fatty Acids Are Associated with Bone Metastasis Formation in Premenopausal Women with Breast Cancer: A Retrospective Study. Nutrients. 2020; 12(12):3832. https://doi.org/10.3390/nu12123832

Chicago/Turabian Style

Goupille, Caroline, Philippe G. Frank, Flavie Arbion, Marie-Lise Jourdan, Cyrille Guimaraes, Michelle Pinault, Gilles Body, Stephan Chevalier, Philippe Bougnoux, and Lobna Ouldamer. 2020. "Low Levels of Omega-3 Long-Chain Polyunsaturated Fatty Acids Are Associated with Bone Metastasis Formation in Premenopausal Women with Breast Cancer: A Retrospective Study" Nutrients 12, no. 12: 3832. https://doi.org/10.3390/nu12123832

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